Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Denmark.
Acta Ophthalmol. 2010 May;88(3):342-6. doi: 10.1111/j.1755-3768.2008.01469.x. Epub 2009 Mar 19.
This study set out to investigate retinal nerve fibre layer (RNFL) thickness and best corrected visual acuity (BCVA) in relation to age in healthy subjects and patients with OPA1 autosomal dominant optic atrophy (DOA).
We carried out a cross-sectional investigation of RNFL thickness and ganglion cell layer density in 30 healthy subjects and 10 patients with OPA1 DOA using optical coherence tomography (OCT). We then performed a regression analysis of RNFL thickness and BCVA versus age.
Both healthy subjects and DOA patients demonstrated a gradual reduction in RNFL thickness with age; the relationship was best described statistically by a model that assumed a constant offset between the two groups. Best corrected VA decreased significantly with age in DOA patients, in whom BCVA was correlated with peripapillary RNFL thickness in the inferior and superior peripapillary quadrants and with total macular thickness at eccentricities of 500-3000 microm. The observations were best described by a constant offset of 41.9 microm separating the two groups and an annual decrease in RNFL thickness of 0.48 microm (p < 0.0001). In patients with DOA, increasing age was associated with decreasing BCVA (p = 0.046).
This cross-sectional study found evidence of comparable age-related decreases in RNFL thickness in healthy subjects and in DOA patients, where the deficit in DOA patients is best described using a model that assumes the deficit between the groups does not vary with age. The gradual reduction of BCVA with age may be a consequence of a relative deficit in RNFL thickness that is established before the second decade of life.
本研究旨在探讨健康受试者和 OPA1 常染色体显性视神经萎缩(DOA)患者的视网膜神经纤维层(RNFL)厚度和最佳矫正视力(BCVA)与年龄的关系。
我们使用光学相干断层扫描(OCT)对 30 名健康受试者和 10 名 OPA1 DOA 患者进行了 RNFL 厚度和节细胞层密度的横断面研究。然后,我们对 RNFL 厚度和 BCVA 与年龄进行了回归分析。
健康受试者和 DOA 患者的 RNFL 厚度均随年龄逐渐降低;统计学上最好的模型假设两组之间存在恒定的偏移量来描述这种关系。DOA 患者的最佳矫正视力(BCVA)随年龄显著下降,在这些患者中,BCVA 与下和上象限视盘周围 RNFL 厚度以及 500-3000μm 偏心度的总黄斑厚度相关。观察结果最好由两个组之间的 41.9μm 的恒定偏移量和 0.48μm/年的 RNFL 厚度的年下降量来描述(p<0.0001)。在 DOA 患者中,年龄的增加与 BCVA 的下降相关(p=0.046)。
本横断面研究发现健康受试者和 DOA 患者的 RNFL 厚度均存在与年龄相关的相似下降,其中 DOA 患者的缺陷最好用一个假设两组之间的缺陷不随年龄变化的模型来描述。随着年龄的增长,BCVA 的逐渐下降可能是 RNFL 厚度相对减少的结果,这种减少发生在生命的第二个十年之前。