Department of Ophthalmology, University Hospital of Cologne, 50924 Cologne, Germany.
Biomed Res Int. 2013;2013:121398. doi: 10.1155/2013/121398. Epub 2013 Aug 19.
To specify thickness values of various retinal layers on macular spectral domain Optical Coherence Tomography (SDOCT) scans in patients with autosomal dominant optic atrophy (ADOA) compared to healthy controls.
SDOCT volume scans of 7 patients with ADOA (OPA-1 mutation) and 14 healthy controls were quantitatively analyzed using manual grading software. Mean thickness values for the ETDRS grid subfields 5-8 were calculated for the spaces neurosensory retina, retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), a combined space of inner plexiform layer/outer plexiform layer/inner nuclear layer (IPL+INL+OPL), and a combined space of outer nuclear layer/photoreceptor layers (ONL+PL).
ADOA patients showed statistically significant lower retinal thickness values than controls (P < 0.01). RNFL (P < 0.001) and GCL thicknesses (P < 0.001) were significantly lower in ADOA patients. There was no difference in IPL+INL+OPL and in ONL+PL thickness.
Manual subanalysis of macular SDOCT volume scans allowed detailed subanalysis of various retinal layers. Not only RNFL but also GCL thicknesses are reduced in the macular area of ADOA patients whereas subjacent layers are not involved. Together with clinical findings, macular SDOCT helps to identify patients with suspicion for hereditary optic neuropathy before genetic analysis confirms the diagnosis.
比较常染色体显性视神经萎缩（ADOA）患者与健康对照者在黄斑区谱域光相干断层扫描（SDOCT）上各视网膜层的厚度值。
对 7 名 ADOA 患者（OPA-1 突变）和 14 名健康对照者的 SDOCT 容积扫描进行定量分析，使用手动分级软件。为了计算神经感觉视网膜、视网膜神经纤维层（RNFL）、节细胞层（GCL）、内丛状层/外丛状层/内核层（IPL+INL+OPL）和外核层/光感受器层（ONL+PL）的 ETDRS 网格子区域 5-8 的平均厚度值。
ADOA 患者的视网膜厚度值明显低于对照组（P<0.01）。ADOA 患者的 RNFL（P<0.001）和 GCL 厚度（P<0.001）明显较低。IPL+INL+OPL 和 ONL+PL 厚度无差异。
对黄斑区 SDOCT 容积扫描的手动亚分析允许对各种视网膜层进行详细的亚分析。不仅是 RNFL，而且 GCL 厚度在 ADOA 患者的黄斑区都减少了，而亚层不受影响。结合临床发现，黄斑区 SDOCT 有助于在遗传分析确认诊断之前识别遗传性视神经病变患者。
