Jones O, Cleveland K O, Gelfand M S
Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38104, USA.
Transpl Infect Dis. 2009 Jun;11(3):281-3. doi: 10.1111/j.1399-3062.2009.00381.x. Epub 2009 Mar 15.
Systemic histoplasmosis is uncommonly reported in patients who have undergone bone marrow or solid organ transplantation. Diagnosis of systemic histoplasmosis in recipients of transplants may be hampered by lack of consideration of this infection in the differential diagnosis and may be confounded by conflicting information from other testing performed to evaluate for opportunistic infections in this population. We report successful treatment of a case of disseminated histoplasmosis in a patient with Hodgkin's lymphoma who had undergone autologous stem cell transplantation. The diagnosis was delayed by the finding of a positive serum galactomannan assay.
系统性组织胞浆菌病在接受骨髓或实体器官移植的患者中鲜有报道。移植受者系统性组织胞浆菌病的诊断可能因鉴别诊断时未考虑这种感染而受到阻碍,也可能因该人群为评估机会性感染而进行的其他检测所提供的相互矛盾的信息而混淆。我们报告了1例霍奇金淋巴瘤患者在接受自体干细胞移植后发生播散性组织胞浆菌病并成功治愈的病例。血清半乳甘露聚糖检测呈阳性的结果导致了诊断延误。