Schwartzman M L, Omata K, Lin F M, Bhatt R K, Falck J R, Abraham N G
Department of Pharmacology, New York Medical College, Valhalla 10595.
Biochem Biophys Res Commun. 1991 Oct 15;180(1):445-9. doi: 10.1016/s0006-291x(05)81313-0.
20-Hydroxyeicosatetraenoic acid (20-HETE), an arachidonate metabolite of the cytochrome P450 omega hydroxylase, was detected in rat urine by gas chromatography-mass spectrometric techniques. The concentration of 20-HETE in urine from 7-week-old hypertensive and normotensive rats was 2.1 and 1.3 nM, respectively. This is the first demonstration of 20-HETE urinary excretion and thus calls attention to the possibility that 20-HETE participates in the regulation of renal function via its effect on vascular tone and ion transport processes.
20-羟基二十碳四烯酸（20-HETE）是细胞色素P450ω羟化酶的花生四烯酸代谢产物，通过气相色谱-质谱技术在大鼠尿液中检测到。7周龄高血压大鼠和正常血压大鼠尿液中20-HETE的浓度分别为2.1 nM和1.3 nM。这是首次证明20-HETE经尿液排泄，因此提醒人们注意20-HETE可能通过影响血管张力和离子转运过程参与肾功能调节。
