多粘菌素B是葡萄糖转运抑制剂的证据。

Evidence that polymyxin B is a glucose transport inhibitor.

作者信息

Goto Y, Kida K, Ikeuchi M, Kaino Y, Matsuda H

机构信息

Department of Pediatrics, Ehime University School of Medicine, Japan.

出版信息

Biochem Pharmacol. 1991 Sep 12;42(7):1399-402. doi: 10.1016/0006-2952(91)90451-a.

DOI:10.1016/0006-2952(91)90451-a

PMID:1930263

Abstract

The effect of polymyxin B on 3-O-methylglucose transport was studied in isolated rat adipocytes and erythrocytes. Polymyxin B (300 micrograms/mL) inhibited basal transport and insulin-stimulated transport of 3-O-methylglucose in adipocytes by 26.1 and 40.1%, respectively. Polymyxin B at concentrations of 300 and 3000 micrograms/mL inhibited transport of 3-O-methylglucose in erythrocytes by 20.0 and 40.8%, respectively. Polymyxin E at a concentration of 3000 micrograms/mL also inhibited, by 40.6%, the transport of 3-O-methylglucose in erythrocytes but 300 micrograms/mL of polymyxin E did not inhibit it significantly. These results indicate that polymyxin B inhibits glucose transport per se, as well as the insulin-dependent stimulation of glucose transport.

摘要

在分离的大鼠脂肪细胞和红细胞中研究了多粘菌素B对3 - O - 甲基葡萄糖转运的影响。多粘菌素B（300微克/毫升）分别使脂肪细胞中3 - O - 甲基葡萄糖的基础转运和胰岛素刺激的转运抑制了26.1%和40.1%。浓度为300和3000微克/毫升的多粘菌素B分别使红细胞中3 - O - 甲基葡萄糖的转运抑制了20.0%和40.8%。浓度为3000微克/毫升的多粘菌素E也使红细胞中3 - O - 甲基葡萄糖的转运抑制了40.6%，但300微克/毫升的多粘菌素E对其抑制作用不显著。这些结果表明，多粘菌素B本身抑制葡萄糖转运，以及胰岛素依赖性的葡萄糖转运刺激。