雏鸡体内血浆脂蛋白代谢对多氯联苯（PCBs）的响应变化。
Changes in plasma lipoprotein metabolism in chicks in response to polychlorinated biphenyls (PCBs).
作者信息
Griffin H, Windsor D, Brolakoglu J
机构信息
AFRC Institute of Animal Physiology and Genetics Research, Roslin, Midlothian, U.K.
出版信息
Biochem Pharmacol. 1991 Sep 12;42(7):1493-5. doi: 10.1016/0006-2952(91)90464-g.
PMID:1930274
Abstract
The results of the present study strongly suggest that the hypertriglyceridaemia in chicks treated with Aroclor 1254 is a result of reduction in VLDL clearance rather than an increase in rate of VLDL secretion. The decrease in post-heparin LPL activity responsible for reduced VLDL clearance may be mediated by cytokines produced by chronic activation of the immune system.
摘要
本研究结果有力地表明，用多氯联苯1254处理的雏鸡出现高甘油三酯血症是极低密度脂蛋白（VLDL）清除率降低的结果，而非VLDL分泌速率增加所致。负责降低VLDL清除率的肝素后脂蛋白脂肪酶（LPL）活性下降可能由免疫系统慢性激活产生的细胞因子介导。
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