Li Michelle W M, Mruk Dolores D, Cheng C Yan
The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, 1230 York Avenue, New York, NY 10065, USA.
Trends Mol Med. 2009 Apr;15(4):159-68. doi: 10.1016/j.molmed.2009.02.002. Epub 2009 Mar 18.
Recent studies have shown that male reproductive function is modulated via the mitogen-activated protein kinase (MAPK) cascade. The MAPK cascade is involved in numerous male reproductive processes, including spermatogenesis, sperm maturation and activation, capacitation and acrosome reaction, before fertilization of the oocyte. In this review, we discuss the latest findings in this rapidly developing field regarding the role of MAPK in male reproduction in animal models and in human spermatozoa in vitro. This research will facilitate the design of future studies in humans, although much work is needed before this information can be used to manage male infertility and environmental toxicant-induced testicular injury in men, such as blood-testis-barrier disruption.
最近的研究表明,雄性生殖功能是通过丝裂原活化蛋白激酶(MAPK)级联反应来调节的。MAPK级联反应参与了许多雄性生殖过程,包括精子发生、精子成熟与激活、获能以及顶体反应,这些过程均发生在卵母细胞受精之前。在这篇综述中,我们讨论了在这个快速发展的领域中关于MAPK在动物模型和体外人精子中的雄性生殖作用的最新发现。尽管在这些信息能够用于治疗男性不育症和环境毒物诱导的男性睾丸损伤(如血睾屏障破坏)之前还需要做大量工作,但这项研究将有助于未来人类研究的设计。