接受抗逆转录病毒治疗的乌干达HIV感染儿童CD4恢复过程中T细胞激活的动态变化
Dynamics of T cell activation accompanying CD4 recovery in antiretroviral treated HIV-infected Ugandan children.
作者信息
Ruel Theodore, Ssewanyana Isaac, Achan Jane, Gasasira Anne, Kamya Moses R, Kekitiinwa Adeodata, Wong Joseph K, Cao Huyen, Havlir Diane, Charlebois Edwin D
机构信息
Department of Pediatrics, Division of Infectious Disease, University of California, San Francisco, San Francisco, CA 94143-0136, USA.
出版信息
Clin Immunol. 2009 Jun;131(3):410-4. doi: 10.1016/j.clim.2009.01.016. Epub 2009 Mar 19.
Africans have elevated T cell activation compared to residents of Europe or the USA. Levels of T cell activation also correlate with disease progression in HIV-infected individuals. We sought to determine if treatment with antiretroviral therapy (ART) would reduce levels of T cell activation (CD38 and HLADR co-expression) in HIV-infected Ugandan children. The median CD8+ T cell activation level among 199 ART-treated children (30%) was lower than in 57 ART-naïve children (45%, p<0.001), but remained higher than in 30 HIV-uninfected children (18%, p<0.001). Among ART-treated children, CD4% was inversely correlated with both CD8- (rho=-0.61, p<0.001) and CD8+ (rho=-0.38, p<0.001) T cell activation. Prospectively, CD4 recovery correlated with post-treatment CD8+ T cell activation level (p=0.008). Our data suggest that significant decreases in T cell activation accompany CD4 recovery in ART-treated HIV-infected African children, to levels that approach but do not reach those of uninfected children.
与欧洲或美国居民相比，非洲人的T细胞活化水平更高。T细胞活化水平也与HIV感染个体的疾病进展相关。我们试图确定抗逆转录病毒疗法（ART）治疗是否会降低HIV感染的乌干达儿童的T细胞活化水平（CD38和HLADR共表达）。199名接受ART治疗的儿童（30%）的CD8 + T细胞活化水平中位数低于57名未接受ART治疗的儿童（45%，p<0.001），但仍高于30名未感染HIV的儿童（18%，p<0.001）。在接受ART治疗的儿童中，CD4%与CD8 - （rho=-0.61，p<0.001）和CD8 + （rho=-0.38，p<0.001）T细胞活化呈负相关。前瞻性研究表明，CD4恢复与治疗后CD8 + T细胞活化水平相关（p=0.008）。我们的数据表明，在接受ART治疗的HIV感染非洲儿童中，T细胞活化水平显著下降伴随着CD4恢复，降至接近但未达到未感染儿童的水平。
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