ATP结合盒转运蛋白A1 R219K基因多态性与心房颤动的关联

[Association of ATP-binding cassette transporter A1 R219K polymorphism with atrial fibrillation].

作者信息

Chen Liang-Chuan, Peng Jian, Lai Wen-Yan, Zeng Guo-Liang, Zhang Zhong-Dong, Tan Zhen-Ni, Deng Wei

机构信息

Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

出版信息

Nan Fang Yi Ke Da Xue Xue Bao. 2009 Mar;29(3):494-6.

PMID:19304534

Abstract

OBJECTIVE

To investigate the association of ATP binding cassette transporter A1 (ABCA1) gene R219K polymorphisms with atrial fibrillation (AF) in Chinese population.

METHODS

A total of 250 patients with AF and 250 control subjects were selected. Polymerase chain reaction-restricted fragments length polymorphism (PCR-RFLP) was used to determine the ABCA1 genotype, and the serum concentration of C-reactive protein (CRP) and high-density lipoprotein cholesterol (HDL-C) were measured in all the subjects.

RESULTS

The frequency of the RR , RK , KK , allele R , allele K genotype of ABCA1 in AF group and control group was 42.0%, 42.8%, 15.2%, 34.0%, 43.2% and 22.8%, 63.4%, 36.6%, 55.6%, 44.4%, respectively. The frequency of the KK genotype was significantly higher in the control group than in the case group (P=0.03), and the frequency of the allele K genotype was significantly different between the two groups (P=0.012). The serum CRP concentrations was significantly higher in AF group than in the control group (P=0.004), but serum HDL-C level showed no difference between the two groups. The serum CRP concentrations were significantly higher in patients with RR genotype than in those with KK genotype (P=0.013), and patients with RR genotype had significantly lower HDL-C level than those with RK and KK genotypes (P=0.009 and 0.027, respectively).

CONCLUSION

Patients with AF have elevated serum CRP level in comparison with healthy individuals, and the K allele of R219K polymorphism is an independent protective factor against AF.

摘要

目的

探讨中国人群中ATP结合盒转运蛋白A1（ABCA1）基因R219K多态性与心房颤动（AF）的相关性。

方法

选取250例AF患者和250例对照者。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）法检测ABCA1基因型，并测定所有受试者血清C反应蛋白（CRP）浓度和高密度脂蛋白胆固醇（HDL-C）水平。

结果

AF组和对照组中ABCA1基因RR、RK、KK基因型频率及等位基因R、等位基因K频率分别为42.0%、42.8%、15.2%、34.0%、43.2%和22.8%、63.4%、36.6%、55.6%、44.4%。对照组KK基因型频率显著高于病例组（P=0.03），两组间等位基因K基因型频率差异有统计学意义（P=0.012）。AF组血清CRP浓度显著高于对照组（P=0.004），但两组间血清HDL-C水平无差异。RR基因型患者血清CRP浓度显著高于KK基因型患者（P=0.013），RR基因型患者HDL-C水平显著低于RK和KK基因型患者（分别为P=0.009和0.027）。