氯沙坦对老年高血压患者左心室肥厚及血浆转化生长因子-β1的影响

[Effects of losartan on left ventricular hypertrophy and plasma transforming growth factor-beta1 in elderly patients with hypertension].

作者信息

Wu Zhen-Li, Xu Ding-Li, Li Yang, Lai Wen-Yan, Huang Peng, Bai Shu-Chang, Su Liang

机构信息

Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

出版信息

Nan Fang Yi Ke Da Xue Xue Bao. 2009 Mar;29(3):531-3.

PMID:19304546

Abstract

OBJECTIVE

To investigate the effects of losartan on left ventricular hypertrophy (LVH) and plasma transforming growth factor-beta1 (TGF-beta1) in elderly patients with essential hypertension (EH).

METHODS

The elderly patients with EH were divided into two groups, namely EH+LVH group and EH group according to the data of echocardiogram. The systolic and diastolic blood pressures of the patients were monitored. Plasma TGF-beta1 was measured before and after 6 months' treatment with losartan, and the relationship between TGF-beta1 and other index were analyzed.

RESULTS

After 6 months' treatment, the blood pressure of EH+LVH group and EH group were significantly lowered (P<0.01). Significant improvement of IVSTd, LVPWd, E/A, and LVMI (P<0.01) and obvious reduction of plasma TGF-beta1 (P<0.01) occurred in EH+LVH group after 6 months' treatment. Correlation analyses indicated that the plasma TGF-beta1 level was positively correlated to LVMI (P<0.01).

CONCLUSION

Losartan can reversed LVH in elderly patients with EH partially by lowering plasma TGF-beta1 level.

摘要

目的

探讨氯沙坦对老年原发性高血压（EH）患者左心室肥厚（LVH）及血浆转化生长因子-β1（TGF-β1）的影响。

方法

根据超声心动图数据，将老年EH患者分为两组，即EH+LVH组和EH组。监测患者的收缩压和舒张压。在氯沙坦治疗6个月前后测定血浆TGF-β1，并分析TGF-β1与其他指标之间的关系。

结果

治疗6个月后，EH+LVH组和EH组血压均显著降低（P<0.01）。EH+LVH组治疗6个月后，室间隔厚度（IVSTd）、左心室后壁厚度（LVPWd）、E/A比值及左心室质量指数（LVMI）显著改善（P<0.01），血浆TGF-β1明显降低（P<0.01）。相关性分析表明，血浆TGF-β1水平与LVMI呈正相关（P<0.01）。