Chadha V, Wright M
Princess Alexandra Eye Pavilion, Chalmers Street, Edinburgh EH3 9HA, UK.
Br J Ophthalmol. 2009 Jun;93(6):803-6. doi: 10.1136/bjo.2008.151183. Epub 2009 Mar 19.
To analyse the outcome of small margin (up to 2 mm) excision of primary clinically well-defined periocular basal cell carcinomas (BCCs).
Retrospective evaluation of 90 well-demarcated primary BCCs having a minimum follow-up of 36 months. All patients underwent excision of the tumour with maximum margins of 2 mm. Resulting defects were, if possible, closed directly. Reconstruction of defects requiring flaps or grafts was delayed until receipt of the histological report which was obtained in all cases.
One-stage excision and direct closure was performed in 67 patients (74.4%). In 23 patients (25.6%) reconstruction was delayed by 4 days to enable receipt of the histopathology report. Histological assessment confirmed complete excision after the first excision in 78 (86.7%) rising to 83 (92.2%) after two excisions. The mean follow-up was 47.5 (SD 9.1) months. Of the 12 cases with incompletely excised lesions, seven of the patients chose not to have any more surgery, and only one of these recurred. There were two other recurrences, and in both of them the lesion had initially been reported as completely excised. Overall the recurrence rate in our study was 3.3% (n = 3).
Our recurrence rate compares well with published results following conventional excision of BCCs. In the absence of availability of Mohs surgery, well-demarcated nodular basal cell carcinomas can be safely excised using smaller margins than conventionally practised.
分析对临床明确的原发性眼周基底细胞癌(BCC)进行小切缘(最大2毫米)切除的结果。
对90例边界清晰的原发性BCC进行回顾性评估,患者至少随访36个月。所有患者均接受肿瘤切除,切缘最大为2毫米。如有可能,直接闭合 resulting 缺损。对于需要皮瓣或植皮的缺损重建,推迟至收到所有病例均获得的组织学报告后进行。
67例患者(74.4%)进行了一期切除并直接闭合。23例患者(25.6%)重建推迟4天,以便获得组织病理学报告。组织学评估证实,首次切除后78例(86.7%)切缘阴性,二次切除后升至83例(92.2%)。平均随访时间为47.5(标准差9.1)个月。在12例切除不完全的病变中,7例患者选择不再接受手术,其中仅1例复发。另外还有2例复发,且最初这2例病变均报告为切缘阴性。总体而言,本研究中的复发率为3.3%(n = 3)。
我们的复发率与已发表的BCC传统切除结果相当。在无法开展莫氏手术的情况下,对于边界清晰的结节性基底细胞癌,可采用比传统方法更小的切缘安全切除。