Caviglia Martina, Kaleci Shaniko, Frascione Pasquale, Teoli Miram, Fargnoli Maria Concetta, Pellacani Giovanni, Mandel Victor Desmond
Dermatologic Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, La Sapienza University of Rome, 00185 Rome, Italy.
Dermatology Unit, Surgical, Medical and Dental Department of Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, 41124 Modena, Italy.
Diagnostics (Basel). 2025 May 14;15(10):1244. doi: 10.3390/diagnostics15101244.
: Basal cell carcinoma (BCC) of the ocular and periocular region is characterized by a painless progressive extension. An early diagnosis can limit the extent of facial tissue involvement and subsequent resection resulting in better cosmetic and functional results. : The aim is to provide the largest and most up-to-date overview of ocular and periocular BCCs. We also reported the first case of caruncle BCC investigated by dermoscopy and reflectance confocal microscopy (RCM). : A systematic review and meta-analysis (Prospero ID CRD583032) were carried out by searching PUBMED-MEDLINE, including all articles with a full-text English version and with BCCs in eyelids, medial and lateral canthus, caruncle, conjunctiva, and orbit. The following data were collected: authors, year, title and type of publication, medical specialization, number, sex, age and comorbidities of the patients, anatomic localization of the disease, clinical and dermoscopic aspect, histological examination, and treatment. : We identified 731 articles through a database search, of which 236 articles matched our inclusion criteria. A total of 71.730 patients with ocular and periocular BCCs were included in the present study, and all data collected were reported in a dataset. Most of the articles included were described by ophthalmologists (67.5%), dermatologists (11.2%), or plastic surgeons (5.6%). The proportional meta-analysis revealed varying significance and heterogeneity for each type of study included. : BCC more frequently affects the lower eyelid. The most common BCC subtype of ocular and periocular area is the nodular form. Limited data are available concerning the application of dermoscopy and RCM in this area. RCM may be particularly useful for early diagnosis, mapping, and treatment monitoring of ocular and periocular BCCs. Surgery still remains the first-choice treatment.
眼及眼周区域的基底细胞癌（BCC）的特征是无痛性进行性扩展。早期诊断可限制面部组织受累范围及后续切除范围，从而获得更好的美容和功能效果。：目的是提供关于眼及眼周基底细胞癌的最大且最新的综述。我们还报告了首例通过皮肤镜和反射式共聚焦显微镜（RCM）研究的泪阜基底细胞癌病例。：通过检索PUBMED - MEDLINE进行系统综述和荟萃分析（Prospero ID CRD583032），纳入所有全文为英文且涉及眼睑、内外眦、泪阜、结膜和眼眶基底细胞癌的文章。收集了以下数据：作者、年份、出版物标题和类型、医学专业、患者数量、性别、年龄和合并症、疾病的解剖定位、临床和皮肤镜表现、组织学检查及治疗方法。：通过数据库检索，我们识别出731篇文章，其中236篇符合我们的纳入标准。本研究共纳入71730例眼及眼周基底细胞癌患者，所有收集的数据均报告在一个数据集中。纳入的文章大多由眼科医生（67.5%）、皮肤科医生（11.2%）或整形外科医生（5.6%）撰写。比例荟萃分析显示，所纳入的每种研究类型的意义和异质性各不相同。：基底细胞癌更常累及下眼睑。眼及眼周区域最常见的基底细胞癌亚型是结节型。关于皮肤镜和RCM在该区域应用的数据有限。RCM可能对眼及眼周基底细胞癌的早期诊断、病变范围确定和治疗监测特别有用。手术仍然是首选治疗方法。
