泰国产OXA-23型碳青霉烯类耐药鲍曼不动杆菌
Carbapenem-resistant Acinetobacter baumannii producing OXA-23 in Thailand.
作者信息
Niumsup Pannika Ritvirool, Boonkerd Nitsara, Tansawai Uttapoln, Tiloklurs Mujarin
机构信息
Department of Microbiology and Parasitology, Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand.
出版信息
Jpn J Infect Dis. 2009 Mar;62(2):152-4.
We investigated the resistance determinant of 13 clinical isolates of carbapenem-resistant Acinetobacter baumannii collected from a regional hospital in the north of Thailand. All isolates were multidrug resistant and produced the OXA-23 carbapenemase. The bla(OXA-23) gene was found adjacent to ISAba1. Furthermore, two isolates carried the metallo beta-lactamase gene, bla(IMP). The bla(OXA-23) and bla(IMP) genes were plasmid-mediated according to the transformation assays. This is the first description of OXA-23-producing A. baumannii from Thailand.
我们对从泰国北部一家地区医院收集的13株耐碳青霉烯鲍曼不动杆菌临床分离株的耐药决定因素进行了研究。所有分离株均对多种药物耐药，并产生OXA-23碳青霉烯酶。发现bla(OXA-23)基因与ISAba1相邻。此外，两株分离株携带金属β-内酰胺酶基因bla(IMP)。根据转化试验，bla(OXA-23)和bla(IMP)基因是质粒介导的。这是泰国产OXA-23鲍曼不动杆菌的首次报道。
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