中国西部产OXA-23碳青霉烯酶的耐碳青霉烯鲍曼不动杆菌暴发。
An outbreak of carbapenem-resistant Acinetobacter baumannii producing OXA-23 carbapenemase in western China.
作者信息
Zong Zhiyong, Lü Xiaoju, Valenzuela Jubelle K, Partridge Sally R, Iredell Jon
机构信息
Department of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
出版信息
Int J Antimicrob Agents. 2008 Jan;31(1):50-4. doi: 10.1016/j.ijantimicag.2007.08.019.
Twenty-two non-repetitive carbapenem-resistant Acinetobacter baumannii isolates were obtained from Intensive Care Unit patients. All of the isolates carried bla(OXA-23), bla(OXA-66), a novel cephalosporinase-encoding gene (bla(ADC-25)) and a class 1 integron with an aacC1-orfP-orfQ-aadA1a cassette array and had identical enterobacterial repetitive intergenic consensus (ERIC) profiles. ISAba1 was found upstream of bla(OXA-23), but was not associated with bla(OXA-66) or bla(ADC-25).
从重症监护病房患者中获得了22株非重复的耐碳青霉烯鲍曼不动杆菌分离株。所有分离株均携带bla(OXA - 23)、bla(OXA - 66)、一个新的头孢菌素酶编码基因(bla(ADC - 25))以及一个带有aacC1 - orfP - orfQ - aadA1a盒式阵列的1类整合子，并且具有相同的肠杆菌重复基因间共识(ERIC)图谱。ISAba1位于bla(OXA - 23)上游，但与bla(OXA - 66)或bla(ADC - 25)无关。
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