精原干细胞中的信号通路及其被毒物破坏的情况。
Signaling pathways in spermatogonial stem cells and their disruption by toxicants.
作者信息
Lucas Benjamin, Fields Christopher, Hofmann Marie-Claude
机构信息
Institute for Genomic Biology, Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois 61822, USA.
出版信息
Birth Defects Res C Embryo Today. 2009 Mar;87(1):35-42. doi: 10.1002/bdrc.20145.
Abstract
Spermatogenesis is a complex biological process that is particularly sensitive to environmental insults such as chemicals and physical stressors. Exposure to specific chemicals has been shown to inhibit fertility through a negative impact on germ cell proliferation and differentiation that can lower sperm count. In addition, toxicants might produce DNA damages that could have negative consequences on the development of the offspring. This review describes spermatogonial stem cell development in the testis, signaling pathways that are crucial for self-renewal, and possible target molecules for environmental toxicants such as phthalate esters and nanoparticles.
摘要
精子发生是一个复杂的生物学过程，对化学物质和物理应激源等环境损伤特别敏感。已表明接触特定化学物质会通过对生殖细胞增殖和分化产生负面影响来抑制生育能力，进而降低精子数量。此外，有毒物质可能会造成DNA损伤，这可能会对后代的发育产生负面影响。这篇综述描述了睾丸中生精干细胞的发育、对自我更新至关重要的信号通路，以及邻苯二甲酸酯和纳米颗粒等环境毒物可能的靶分子。
相似文献
1
Signaling pathways in spermatogonial stem cells and their disruption by toxicants.精原干细胞中的信号通路及其被毒物破坏的情况。
Birth Defects Res C Embryo Today. 2009 Mar;87(1):35-42. doi: 10.1002/bdrc.20145.
2
Transgenerational effects of di-(2-ethylhexyl) phthalate on testicular germ cell associations and spermatogonial stem cells in mice.邻苯二甲酸二（2-乙基己基）酯对小鼠睾丸生殖细胞联系和精原干细胞的跨代效应。
Biol Reprod. 2013 May 2;88(5):112. doi: 10.1095/biolreprod.112.106104. Print 2013 May.
3
Characterization of spermatogonial stem cell maturation and differentiation in neonatal mice.新生小鼠精原干细胞成熟与分化的特征分析
Biol Reprod. 2003 Dec;69(6):2085-91. doi: 10.1095/biolreprod.103.017020. Epub 2003 Sep 3.
4
Mono-(2-ethylhexyl)-phthalate (MEHP) affects ERK-dependent GDNF signalling in mouse stem-progenitor spermatogonia.邻苯二甲酸二（2-乙基己基）酯（MEHP）影响 ERK 依赖性 GDNF 信号在小鼠干细胞-前体精原细胞中的作用。
Toxicology. 2012 Sep 4;299(1):10-9. doi: 10.1016/j.tox.2012.04.011. Epub 2012 Apr 27.
5
Characterizing the Spermatogonial Response to Retinoic Acid During the Onset of Spermatogenesis and Following Synchronization in the Neonatal Mouse Testis.在新生小鼠睾丸精子发生起始阶段及同步化后，对维甲酸的精原细胞反应进行特征描述。
Biol Reprod. 2016 Oct;95(4):81. doi: 10.1095/biolreprod.116.141770. Epub 2016 Aug 3.
6
Silver nanoparticles disrupt GDNF/Fyn kinase signaling in spermatogonial stem cells.银纳米颗粒破坏精原干细胞中的 GDNF/Fyn 激酶信号通路。
Toxicol Sci. 2010 Aug;116(2):577-89. doi: 10.1093/toxsci/kfq148. Epub 2010 May 20.
7
Cell-autonomous requirement for mammalian target of rapamycin (Mtor) in spermatogonial proliferation and differentiation in the mouse†.雷帕霉素哺乳动物靶蛋白（Mtor）在小鼠精原细胞增殖和分化中的细胞自主需求†
Biol Reprod. 2017 Apr 1;96(4):816-828. doi: 10.1093/biolre/iox022.
8
Foxo1 is required in mouse spermatogonial stem cells for their maintenance and the initiation of spermatogenesis.Foxo1 在小鼠精原干细胞中对于其维持和精子发生的起始是必需的。
J Clin Invest. 2011 Sep;121(9):3456-66. doi: 10.1172/JCI57984. Epub 2011 Aug 25.
9
Fertility restoration with spermatogonial stem cells.利用精原干细胞恢复生育能力。
Curr Opin Endocrinol Diabetes Obes. 2017 Dec;24(6):424-431. doi: 10.1097/MED.0000000000000370.
10
Defining the cellular and molecular mechanisms of toxicant action in the testis.确定睾丸中毒物作用的细胞和分子机制。
Toxicol Lett. 2002 Oct 5;135(3):167-83. doi: 10.1016/s0378-4274(02)00254-0.
引用本文的文献
1
Germ cells and the aging niche: a systems approach to reproductive longevity.生殖细胞与衰老微环境：一种探讨生殖寿命的系统方法。
J Assist Reprod Genet. 2025 May 29. doi: 10.1007/s10815-025-03518-1.
2
Application of testicular organ culture system for the evaluation of spermatogenesis impairment.睾丸器官培养系统在评估生精障碍中的应用。
Sci Rep. 2024 Sep 16;14(1):21581. doi: 10.1038/s41598-024-71561-6.
3
Bisphenols Threaten Male Reproductive Health via Testicular Cells.双酚类物质通过睾丸细胞威胁男性生殖健康。
Front Endocrinol (Lausanne). 2020 Sep 11;11:624. doi: 10.3389/fendo.2020.00624. eCollection 2020.
4
Proposed Key Characteristics of Male Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Evidence in Human Health Hazard Assessments.提出生殖毒物的关键特征，作为在人类健康危害评估中组织和评估机制证据的一种方法。
Environ Health Perspect. 2019 Jun;127(6):65001. doi: 10.1289/EHP5045. Epub 2019 Jun 14.
5
The Impact of Bisphenol A on Fertility, Reproductive System, and Development: A Review of the Literature.双酚A对生育力、生殖系统及发育的影响：文献综述
Int J Endocrinol. 2019 Apr 10;2019:4068717. doi: 10.1155/2019/4068717. eCollection 2019.
6
The hypothalamic-pituitary-testicular axis and the testicular function are modulated after silver nanoparticle exposure.银纳米颗粒暴露后，下丘脑-垂体-睾丸轴及睾丸功能受到调节。
Toxicol Res (Camb). 2017 Nov 23;7(1):102-116. doi: 10.1039/c7tx00236j. eCollection 2018 Jan 1.
7
Internalization of silver nanoparticles into mouse spermatozoa results in poor fertilization and compromised embryo development.银纳米颗粒内化进入小鼠精子会导致受精不良和胚胎发育受损。
Sci Rep. 2015 Jun 8;5:11170. doi: 10.1038/srep11170.
8
Engineered nanomaterials: an emerging class of novel endocrine disruptors.工程纳米材料：一类新兴的新型内分泌干扰物。
Biol Reprod. 2014 Jul;91(1):20. doi: 10.1095/biolreprod.113.116244. Epub 2014 Jun 4.
9
Sub-acute intravenous administration of silver nanoparticles in male mice alters Leydig cell function and testosterone levels.雄性小鼠亚急性静脉注射银纳米颗粒会改变睾丸间质细胞功能和睾酮水平。
Reprod Toxicol. 2014 Jun;45:59-70. doi: 10.1016/j.reprotox.2014.01.006. Epub 2014 Jan 18.
10
The apical ES-BTB-BM functional axis is an emerging target for toxicant-induced infertility.顶端 ES-BTB-BM 功能轴是毒物诱导不孕的一个新兴靶点。
Trends Mol Med. 2013 Jul;19(7):396-405. doi: 10.1016/j.molmed.2013.03.006. Epub 2013 May 2.
本文引用的文献
1
Concentrations of phthalate metabolites in milk, urine, saliva, and Serum of lactating North Carolina women.北卡罗来纳州哺乳期妇女的乳汁、尿液、唾液和血清中邻苯二甲酸酯代谢物的浓度。
Environ Health Perspect. 2009 Jan;117(1):86-92. doi: 10.1289/ehp.11610. Epub 2008 Aug 22.
2
Phthalates impair germ cell development in the human fetal testis in vitro without change in testosterone production.邻苯二甲酸盐在体外会损害人类胎儿睾丸中的生殖细胞发育，而不会改变睾酮的产生。
Environ Health Perspect. 2009 Jan;117(1):32-7. doi: 10.1289/ehp.11146. Epub 2008 Sep 9.
3
Effects of in utero exposure to nanoparticle-rich diesel exhaust on testicular function in immature male rats.子宫内暴露于富含纳米颗粒的柴油废气对未成熟雄性大鼠睾丸功能的影响。
Toxicol Lett. 2009 Feb 25;185(1):1-8. doi: 10.1016/j.toxlet.2008.11.012. Epub 2008 Nov 28.
4
Sperm head defects and disturbances in spermatozoal chromatin and DNA integrities in idiopathic infertile subjects: association with cigarette smoking.特发性不育患者的精子头部缺陷以及精子染色质和DNA完整性的紊乱：与吸烟的关联
Clin Biochem. 2009 May;42(7-8):589-94. doi: 10.1016/j.clinbiochem.2008.11.012. Epub 2008 Dec 6.
5
Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity.造血干细胞的功能和存活依赖于c-Myc和N-Myc的活性。
Cell Stem Cell. 2008 Dec 4;3(6):611-24. doi: 10.1016/j.stem.2008.09.005.
6
Time-response effects of testicular gene expression profiles in Sprague-Dawley male rats treated with di(n-butyl) phthalate.邻苯二甲酸二丁酯处理的Sprague-Dawley雄性大鼠睾丸基因表达谱的时间响应效应
J Toxicol Environ Health A. 2008;71(23):1542-9. doi: 10.1080/15287390802391992.
7
Cross-talk between the Akt and NF-kappaB signaling pathways inhibits MEHP-induced germ cell apoptosis.Akt与核因子κB信号通路之间的相互作用抑制了单（2-乙基己基）邻苯二甲酸酯诱导的生殖细胞凋亡。
Toxicol Sci. 2008 Dec;106(2):497-508. doi: 10.1093/toxsci/kfn186. Epub 2008 Aug 28.
8
Health effects related to nanoparticle exposures: environmental, health and safety considerations for assessing hazards and risks.与纳米颗粒暴露相关的健康影响：评估危害和风险的环境、健康与安全考量
Pharmacol Ther. 2008 Oct;120(1):35-42. doi: 10.1016/j.pharmthera.2008.07.001. Epub 2008 Jul 19.
9
Drug delivery and nanoparticles:applications and hazards.药物递送与纳米颗粒：应用与危害
Int J Nanomedicine. 2008;3(2):133-49. doi: 10.2147/ijn.s596.
10
Regulation of spermatogonial stem cell self-renewal in mammals.哺乳动物精原干细胞自我更新的调控
Annu Rev Cell Dev Biol. 2008;24:263-86. doi: 10.1146/annurev.cellbio.24.110707.175355.
Zotero 插件