Lucas Benjamin, Fields Christopher, Hofmann Marie-Claude
Institute for Genomic Biology, Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois 61822, USA.
Birth Defects Res C Embryo Today. 2009 Mar;87(1):35-42. doi: 10.1002/bdrc.20145.
Spermatogenesis is a complex biological process that is particularly sensitive to environmental insults such as chemicals and physical stressors. Exposure to specific chemicals has been shown to inhibit fertility through a negative impact on germ cell proliferation and differentiation that can lower sperm count. In addition, toxicants might produce DNA damages that could have negative consequences on the development of the offspring. This review describes spermatogonial stem cell development in the testis, signaling pathways that are crucial for self-renewal, and possible target molecules for environmental toxicants such as phthalate esters and nanoparticles.
精子发生是一个复杂的生物学过程，对化学物质和物理应激源等环境损伤特别敏感。已表明接触特定化学物质会通过对生殖细胞增殖和分化产生负面影响来抑制生育能力，进而降低精子数量。此外，有毒物质可能会造成DNA损伤，这可能会对后代的发育产生负面影响。这篇综述描述了睾丸中生精干细胞的发育、对自我更新至关重要的信号通路，以及邻苯二甲酸酯和纳米颗粒等环境毒物可能的靶分子。
