心肌血流定量：其临床作用是什么？

Quantification of myocardial blood flow: what is the clinical role?

作者信息

Schelbert Heinrich R

机构信息

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095-6948, USA.

出版信息

Cardiol Clin. 2009 May;27(2):277-89, Table of Contents. doi: 10.1016/j.ccl.2008.12.009.

DOI:10.1016/j.ccl.2008.12.009

PMID:19306770

Abstract

Quantification of regional myocardial blood flow and of its responses to targeted physiologic and pharmacologic interventions, which is now available with positron emitting tracers of blood flow and positron emission tomography (PET), extends the diagnostic potential of standard myocardial perfusion imaging. These noninvasive flow measurements serve as tools for quantifying functional consequences of epicardial coronary artery disease, as well as of impairments in microcirculatory reactivity that escape detection by standard perfusion imaging. Flow measurements are clinically useful for more comprehensively assessing the extent and severity of coronary vascular disease or impairments in microcirculatory function in noncoronary cardiac disease. Flow estimates in these disorders contain independent or unique prognostic information about future major cardiac events. Flow measurements are also useful for assessing the coronary risk, for predicting long-term cardiovascular events, and for monitoring the effectiveness of risk reduction strategies.

摘要

利用正电子发射型血流示踪剂和正电子发射断层扫描（PET）技术，现在可以对局部心肌血流量及其对特定生理和药物干预的反应进行定量分析，这扩展了标准心肌灌注成像的诊断潜力。这些非侵入性血流测量方法可作为量化心外膜冠状动脉疾病功能后果的工具，也可用于量化标准灌注成像无法检测到的微循环反应性损伤。血流测量在临床上有助于更全面地评估冠状动脉血管疾病的范围和严重程度，或非冠状动脉疾病中的微循环功能损伤。这些疾病中的血流估计包含有关未来重大心脏事件的独立或独特的预后信息。血流测量还可用于评估冠状动脉风险、预测长期心血管事件以及监测降低风险策略的有效性。