Koskenvuo J W, Hartiala J J, Knuuti J, Sakuma H, Toikka J O, Komu M, Saraste M, Niemi P
Department of Clinical Physiology, Turku University Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland.
AJR Am J Roentgenol. 2001 Nov;177(5):1161-6. doi: 10.2214/ajr.177.5.1771161.
This study was performed to determine whether MR imaging can be used to reliably measure global myocardial blood flow and coronary flow reserve in patients with coronary artery disease as compared with such measurements obtained by positron emission tomography (PET).
We measured myocardial blood flow first at baseline and then after dipyridamole-induced hyperemia in 20 patients with coronary artery disease. Myocardial blood flow as revealed by MR imaging was calculated by dividing coronary sinus flow by the left ventricular mass. Coronary flow reserve was calculated by dividing the rate of hyperemic flow by the rate of baseline flow.
Using MR imaging, myocardial blood flow at baseline was 0.73 +/- 0.23 mL x min(-1) x g(-1), and at hyperemia the blood flow was 1.43 +/- 0.37 mL x min(-1) x g(-1), yielding an average coronary flow reserve of 1.99 +/- 0.47. Using PET, myocardial blood flow was 0.89 +/- 0.21 mL x min(-1) x g(-1) at baseline and 1.56 +/- 0.42 mL x min(-1) x g(-1) at hyperemia, yielding an average coronary flow reserve of 1.77 +/- 0.36. The correlation of myocardial blood flow and coronary flow reserve measurements for these two methods was an r of 0.80 (p < 0.01) and an r of 0.50 (p < 0.05), respectively.
This study shows that myocardial blood flow measurements obtained using MR imaging have a good correlation with corresponding PET measurements. Coronary flow reserve measurements obtained using MR imaging had only moderate correlation with PET-obtained measurements. Our results suggest that MR imaging flow quantification could potentially be used for measuring global myocardial blood flow in patients in whom interventional treatment for coronary artery disease is being evaluated.
本研究旨在确定与正电子发射断层扫描（PET）所获得的测量值相比，磁共振成像（MR成像）是否可用于可靠地测量冠心病患者的整体心肌血流量和冠状动脉血流储备。
我们在20例冠心病患者中，首先在基线时测量心肌血流量，然后在双嘧达莫诱发充血后再次测量。通过将冠状窦血流量除以左心室质量来计算MR成像所显示的心肌血流量。通过将充血期血流量速率除以基线期血流量速率来计算冠状动脉血流储备。
使用MR成像，基线时心肌血流量为0.73±0.23 mL·min⁻¹·g⁻¹，充血时血流量为1.43±0.37 mL·min⁻¹·g⁻¹，平均冠状动脉血流储备为1.99±0.47。使用PET，基线时心肌血流量为0.89±0.21 mL·min⁻¹·g⁻¹，充血时为1.56±0.42 mL·min⁻¹·g⁻¹，平均冠状动脉血流储备为1.77±0.36。这两种方法测量的心肌血流量和冠状动脉血流储备的相关性分别为r = 0.80（p < 0.01）和r = 0.50（p < 0.05）。
本研究表明，使用MR成像获得的心肌血流量测量值与相应的PET测量值具有良好的相关性。使用MR成像获得的冠状动脉血流储备测量值与PET获得的测量值仅具有中等相关性。我们的结果表明，MR成像血流定量可能潜在地用于测量正在接受冠状动脉疾病介入治疗评估的患者的整体心肌血流量。
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