Cogswell J P, Zeleznik-Le N, Ting J P
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599-7295.
Crit Rev Immunol. 1991;11(2):87-112.
Class II Major Histocompatibility Complex (MHC) products are essential initiators of cellular immune responses. Their cell surface expression demonstrates aspects of tissue-restricted, inducible, differentiation-dependent, and coordinate regulation indicative of complex molecular controls mediated primarily at the level of transcription. This article reviews our current understanding of transcriptional regulation of one such human class II MHC gene, DRA. Considerable effort has been exerted toward characterizing the cis-acting regulatory sequences and trans-acting DNA binding proteins responsible for regulating DRA transcription. Recent application of novel molecular techniques has resulted in the cloning and characterization of some of these regulatory proteins. A model is presented herein which accommodates the current knowledge of DRA gene regulation.
II类主要组织相容性复合体（MHC）产物是细胞免疫反应的重要启动因子。它们在细胞表面的表达展示了组织限制性、可诱导性、分化依赖性和协调性调节等方面，这些调节表明主要在转录水平介导的复杂分子控制。本文综述了我们目前对一种人类II类MHC基因DRA转录调控的理解。人们已经付出了相当大的努力来表征负责调节DRA转录的顺式作用调节序列和反式作用DNA结合蛋白。新型分子技术的最新应用已导致其中一些调节蛋白的克隆和表征。本文提出了一个模型，该模型涵盖了目前关于DRA基因调控的知识。
