Cubells A B, Dalmau L B, Petrone M E, Chaknis P, Volpe A R
Institut d'Odontologia Preventiva, Barcelona, Spain.
J Clin Dent. 1991;2(3):63-9.
A total of 108 adult male and female subjects completed a six-month, double-blind clinical study designed to compare the effect of a dentifrice containing 0.3% triclosan and 2.0% of a copolymer of methoxyethylene and maleic acid (Gantrez copolymer) in a 0.243% sodium fluoride/silica base to a 0.243% sodium fluoride/silica placebo dentifrice on supragingival plaque formation and gingivitis. Subjects were stratified into two balanced groups by their baseline plaque and gingivitis scores. They received an oral prophylaxis and were assigned to use either the triclosan/copolymer dentifrice or the placebo dentifrice for the next six months. After six months, the dentifrice containing triclosan/copolymer provided a 24.93% statistically significant (99% level of confidence) reduction in supragingival plaque, and a 19.72% statistically significant (99% level of confidence) reduction in gingivitis compared to the placebo dentifrice. Twice daily use of a dentifrice containing 0.3% triclosan, 2.0% of a copolymer, and 0.243% sodium fluoride in a silica base, over a six-month period, reduces supragingival plaque formation and gingivitis to a significant degree compared to a sodium fluoride/silica base placebo dentifrice.
共有108名成年男性和女性受试者完成了一项为期6个月的双盲临床研究，该研究旨在比较一种含0.3%三氯生和2.0%甲氧基乙烯与马来酸共聚物（甘泰树脂共聚物）的0.243%氟化钠/二氧化硅基牙膏与一种0.243%氟化钠/二氧化硅基安慰剂牙膏对龈上菌斑形成和牙龈炎的影响。受试者根据其基线菌斑和牙龈炎评分被分层为两个均衡的组。他们接受了口腔预防治疗，并被分配在接下来的6个月内使用三氯生/共聚物牙膏或安慰剂牙膏。6个月后，与安慰剂牙膏相比，含三氯生/共聚物的牙膏使龈上菌斑减少了24.93%，具有统计学显著意义（99%置信水平），使牙龈炎减少了19.72%，具有统计学显著意义（99%置信水平）。在6个月的时间里，每天两次使用含0.3%三氯生、2.0%共聚物和0.243%氟化钠的二氧化硅基牙膏，与氟化钠/二氧化硅基安慰剂牙膏相比，能显著减少龈上菌斑形成和牙龈炎。
