Schiff T, Cohen S, Volpe A R, Petrone M E
School of Dental Medicine, Washington University, St. Louis, Missouri.
Am J Dent. 1990 Sep;3 Spec No:S43-5.
A 12-week, double-blind, parallel and unsupervised clinical study was conducted to compare the effects on supragingival calculus formation of two dentifrices containing triclosan (Irgacare MP) and a copolymer of methoxyethylene and maleic acid (Gantrez) as compared to a placebo dentifrice. All 147 adult male and female subjects completed the study. Subjects were stratified into three balanced groups on the basis of their Volpe-Manhold index calculus scores as obtained from a 3-month pre-test period using a placebo dentifrice. After a complete oral prophylaxis, subjects were assigned to the use of either the placebo dentifrice, a dentifrice containing 0.3% triclosan and 2.0% of a copolymer in a 0.243% sodium fluoride silica base, or a dentifrice containing 0.3% triclosan and 2.0% of a coplymer in a 0.76% sodium monofluorophosphate alumina base. Subjects, after brushing with their assigned dentifrice and soft-bristled toothbrush for 12 weeks, were evaluated by the examining dentist for supragingival calculus formation using the Volpe-Manhold assessment method. These examinations showed that the dentifrice containing 0.3% triclosan/2.0% copolymer in a 0.243% sodium fluoride silica base reduced supragingival calculus deposits by 23.12% and the dentifrice containing 0.3% triclosan/2.0% copolymer in a 0.76% sodium monofluorophosphate alumina base reduced supragingival calculus deposits by 26.15%. Both of these reductions in supragingival calculus were compared to the placebo dentifrice and were statistically significant at the 99% level of confidence.
进行了一项为期12周的双盲、平行且无监督的临床研究，以比较两种含三氯生（玉洁纯MP）和甲氧基乙烯与马来酸共聚物（甘泰）的牙膏与一种安慰剂牙膏对龈上牙石形成的影响。147名成年男性和女性受试者均完成了该研究。根据使用安慰剂牙膏进行的为期3个月的预测试期所获得的Volpe-Manhold指数牙石评分，将受试者分为三个均衡组。在进行全面的口腔预防治疗后，受试者被分配使用安慰剂牙膏、一种含0.3%三氯生和2.0%共聚物的0.243%氟化钠二氧化硅基质牙膏，或一种含0.3%三氯生和2.0%共聚物的0.76%单氟磷酸钠氧化铝基质牙膏。受试者使用分配的牙膏和软毛牙刷刷牙12周后，由检查牙医使用Volpe-Manhold评估方法对龈上牙石形成情况进行评估。这些检查表明，含0.3%三氯生/2.0%共聚物的0.243%氟化钠二氧化硅基质牙膏使龈上牙石沉积减少了23.12%，含0.3%三氯生/2.0%共聚物的0.76%单氟磷酸钠氧化铝基质牙膏使龈上牙石沉积减少了26.15%。与安慰剂牙膏相比，这两种龈上牙石减少情况在99%的置信水平上具有统计学意义。
