新型14型腺病毒的受体使用情况
Receptor usage of a newly emergent adenovirus type 14.
作者信息
Wang Hongjie, Tuve Sebastian, Erdman Dean D, Lieber André
机构信息
University of Washington, Seattle, 98195, USA.
出版信息
Virology. 2009 May 10;387(2):436-41. doi: 10.1016/j.virol.2009.02.034.
Abstract
Recently, cases of severe respiratory illness in military and civilian populations have been associated with a new genomic variant of adenovirus (Ad) serotype 14, designated Ad14a. Compared to the Ad14 reference strain (de Wit), this new virus had a deletion of two amino acid residues in the fiber protein knob. Here we tested whether this mutation changed receptor usage of Ad14a compared to Ad14-de Wit. Competition studies with radio-labeled viruses revealed that both Ad14-de Wit and Ad14a used the same receptor which is hitherto unknown. We also found that recombinant fiber knobs only partially blocked attachment of Ad14a, indicating that virus capsid proteins other than the fiber are involved in infection.
摘要
最近，军队和平民中出现的严重呼吸道疾病病例与腺病毒（Ad）血清型14的一种新基因组变体有关，该变体被命名为Ad14a。与Ad14参考菌株（德威特）相比，这种新病毒的纤维蛋白钮中有两个氨基酸残基缺失。在这里，我们测试了与Ad14-德威特相比，这种突变是否改变了Ad14a的受体使用情况。用放射性标记病毒进行的竞争研究表明，Ad14-德威特和Ad14a都使用相同的受体，而该受体迄今尚不清楚。我们还发现，重组纤维钮只能部分阻断Ad14a的附着，这表明除纤维外的病毒衣壳蛋白也参与了感染。
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