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黄烷酮衍生物的结构与其增强早期生长反应-1基因表达的作用之间的关系。

Relationships between the structures of flavanone derivatives and their effects in enhancing early growth response-1 gene expression.

作者信息

Lee Sunhee, Woo Yoonkyung, Shin Soon Young, Lee Young Han, Lim Yoongho

机构信息

Division of Bioscience and Biotechnology, BMIC, RCD, Konkuk University, Seoul, Republic of Korea.

出版信息

Bioorg Med Chem Lett. 2009 Apr 15;19(8):2116-20. doi: 10.1016/j.bmcl.2009.03.017. Epub 2009 Mar 10.

DOI:10.1016/j.bmcl.2009.03.017
PMID:19307119
Abstract

To identify the structural requirements that are pivotal in enhancing Early growth response-1 (Egr-1) expression, the quantitative relationships between the structural properties of flavanone derivatives and their increments of Egr-1 expression were elucidated using comparative molecular field analysis and comparative molecular similarity indices analysis.

摘要

为了确定增强早期生长反应因子-1（Egr-1）表达的关键结构要求，利用比较分子场分析和比较分子相似性指数分析阐明了黄烷酮衍生物的结构性质与其Egr-1表达增量之间的定量关系。

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