Hansen S, Harthon C, Wallin E, Löfberg L, Svensson K
Department of Psychology, University of Göteborg, Sweden.
Behav Neurosci. 1991 Aug;105(4):588-98. doi: 10.1037//0735-7044.105.4.588.
The effects of lesions to the mesolimbic dopamine system on maternal and sexual behaviors in the female rat was assessed. Rat dams that were given ventral tegmental area microinfusions of 6-hydroxydopamine (6-OHDA) during lactation showed a persistent deficit in pup retrieval but were not impaired with respect to nursing, nest building, or maternal aggression. In addition, 6-OHDA-lesioned females failed to respond to amphetamine by showing locomotor hyperactivity. Administration of the dopamine blocker raclopride to neurologically intact dams also inhibited pup retrieval but had no effect on nursing. Females given 6-OHDA during pregnancy appeared completely unresponsive to pups, whereas no maternal deficits were seen in females that received 6-OHDA 8 weeks before parturition. Proceptive (hopping and darting) and receptive (lordosis) components of sexual behavior, assessed after ovariectomy and exogenous steroid hormone treatment, were not affected by mesolimbic 6-OHDA lesions.
评估了中脑边缘多巴胺系统损伤对雌性大鼠母性行为和性行为的影响。在哺乳期接受腹侧被盖区微量注射6-羟基多巴胺（6-OHDA）的母鼠，在找回幼崽方面表现出持续的缺陷，但在哺乳、筑巢或母性攻击方面没有受损。此外，6-OHDA损伤的雌性大鼠对苯丙胺没有表现出运动性多动反应。向神经功能正常的母鼠施用多巴胺阻滞剂雷氯必利也会抑制找回幼崽的行为，但对哺乳没有影响。在怀孕期间接受6-OHDA的雌性大鼠似乎对幼崽完全无反应，而在分娩前8周接受6-OHDA的雌性大鼠未出现母性缺陷。在卵巢切除和外源性类固醇激素治疗后评估的性行为的接受前（跳跃和飞奔）和接受（脊柱前凸）成分，不受中脑边缘6-OHDA损伤的影响。
