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一例因摄入朝鲜蓖麻子导致的蓖麻毒素中毒病例。

A case of ricin poisoning following ingestion of Korean castor bean.

作者信息

Lim H, Kim H J, Cho Y S

机构信息

Department of Emergency Medicine, College of Medicine, Bucheon Hospital, Sooncheonhyang University, Bucheon, Republic of Korea.

出版信息

Emerg Med J. 2009 Apr;26(4):301-2. doi: 10.1136/emj.2007.055368.

DOI:10.1136/emj.2007.055368
PMID:19307402
Abstract

Ricin is a member of a group of protein toxins whose cytosolic target is the 28S rRNA of the 60S ribosomal subunit. It was recently introduced as a weapon of terrorism in some countries. There is little evidence about the mechanism, diagnosis and treatment of ricin poisoning. The case history is reported of a patient with ricin poisoning who presented with nausea and vomiting following ingestion of Korean castor bean.

摘要

蓖麻毒素是一组蛋白质毒素中的一员,其胞质靶标是60S核糖体亚基的28S核糖体RNA。最近在一些国家,它被用作恐怖主义武器。关于蓖麻毒素中毒的机制、诊断和治疗的证据很少。本文报告了一例蓖麻毒素中毒患者的病例,该患者因食用朝鲜蓖麻子后出现恶心和呕吐。

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Emerg Med J. 2009 Apr;26(4):301-2. doi: 10.1136/emj.2007.055368.
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The Search for Antidotes Against Ricin.寻找蓖麻毒素解毒剂。
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Quantification of Ricinine and Abrine in Human Plasma by HPLC-MS-MS: Biomarkers of Exposure to Ricin and Abrin.采用高效液相色谱-串联质谱法测定人血浆中蓖麻碱和相思豆毒蛋白:蓖麻毒素和相思子毒素暴露的生物标志物
J Anal Toxicol. 2018 Nov 1;42(9):630-636. doi: 10.1093/jat/bky040.
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Toxins (Basel). 2015 Nov 26;7(12):4967-86. doi: 10.3390/toxins7124858.
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A computational perspective of molecular interactions through virtual screening, pharmacokinetic and dynamic prediction on ribosome toxin A chain and inhibitors of Ricinus communis.通过虚拟筛选、药代动力学以及对蓖麻毒素A链和蓖麻毒素抑制剂的动力学预测来研究分子相互作用的计算视角
Pharmacognosy Res. 2012 Jan;4(1):2-10. doi: 10.4103/0974-8490.91027.
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Ricinus communis intoxications in human and veterinary medicine-a summary of real cases.蓖麻中毒在人类和兽医医学中的应用——真实案例综述。
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