在与溶瘤融合性单纯疱疹病毒1型（OncdSyn）的联合治疗中，沙利度胺抑制了4T1细胞在Balb/c小鼠体内形成实体瘤的生长。
Thalidomide suppressed the growth of 4T1 cells into solid tumors in Balb/c mice in a combination therapy with the oncolytic fusogenic HSV-1 OncdSyn.
作者信息
Israyelyan Anna, Shannon Edward John, Baghian Abolghasem, Kearney Michael T, Kousoulas Konstantin G
机构信息
Division of Biotechnology and Molecular Medicine, Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.
出版信息
Cancer Chemother Pharmacol. 2009 Nov;64(6):1201-10. doi: 10.1007/s00280-009-0987-8. Epub 2009 Mar 24.
PURPOSE
The anti-tumor properties of thalidomide or in combination with an oncolytic herpes virus (OncdSyn) was investigated in a mouse model of human breast cancer.
METHODS
To determine if thalidomide could act alone, 4T1 cells were injected into Balb/c mice. Tumors were sized, and the mice were fed chow or chow-containing thalidomide. After 4 days the tumor volumes were compared. To determine if thalidomide could act with the virus, tumors of mice were injected with phosphate buffered saline (PBS), or fed thalidomide with injections of PBS, or fed thalidomide with injections of OncdSyn, or received injections of OncdSyn.
RESULTS
Thalidomide alone suppressed tumor growth. The most significant treatment occurred in thalidomide-fed-OncdSyn-injected mice. Compared to PBS controls, there was a significant difference in the number of metastatic nodes in the lungs.
CONCLUSIONS
Thalidomide alone delayed tumor growth, but the combination of thalidomide with OncdSyn appeared to produce the best results.
目的
在人乳腺癌小鼠模型中研究沙利度胺或其与溶瘤性疱疹病毒（OncdSyn）联合使用的抗肿瘤特性。
方法
为确定沙利度胺是否能单独发挥作用，将4T1细胞注射到Balb/c小鼠体内。测量肿瘤大小，给小鼠喂食普通食物或含沙利度胺的食物。4天后比较肿瘤体积。为确定沙利度胺是否能与病毒协同作用，给小鼠肿瘤注射磷酸盐缓冲盐水（PBS），或喂食沙利度胺并注射PBS，或喂食沙利度胺并注射OncdSyn，或注射OncdSyn。
结果
单独使用沙利度胺可抑制肿瘤生长。最显著的治疗效果出现在喂食沙利度胺并注射OncdSyn的小鼠身上。与PBS对照组相比，肺部转移结节数量有显著差异。
结论
单独使用沙利度胺可延缓肿瘤生长，但沙利度胺与OncdSyn联合使用似乎能产生最佳效果。
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