Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, PO Box 301402, Houston, TX 77230-1402, USA.
World J Surg. 2009 Nov;33(11):2292-302. doi: 10.1007/s00268-009-9966-9.
Research into the actions of vitamin D on the human body has been increasing at an exponential rate, as has understanding of the impact of vitamin D on various aspects of the endocrine system. Primary hyperparathyroidism (PHPT) is a disease of the endocrine system that can result in debility if not diagnosed. New understanding about the effect of vitamin D on parathyroid hormone regulation may provide an opportunity to better understand the coexistence of PHPT and vitamin D deficiency.
An evidence-based literature review was based on a PubMed search for research involving vitamin D and primary hyperparathyroidism, and evaluating existing research on vitamin D. The PubMed search included English-language articles published between 1977 and 2008, with a focus on research and analysis completed between 2005 and the present. This study examined recent developments in understanding the relationship between vitamin D and PHPT. This review of existing literature examined the impact of vitamin D insufficiency and deficiency, including the impact on diagnosis of vitamin D insufficiency/deficiency, diagnosis and management of PHPT, and the impact on overall health. The level of evidence was determined according to criteria proposed by Sackett et al. and the grade of recommendation according to the criteria proposed by Heinrich et al.
Level III and level IV evidence predominates the vitamin D/PHPT based literature, with several notable Heinrich grade A, B, and C studies available. Additional evaluation of studies' review is provided by reference and by section.
Vitamin D metabolism plays an important role in PHPT etiology, diagnosis, and management. Care of both conditions may have an important impact on overall health in humans.
随着对维生素 D 对人体作用的研究呈指数级增长，人们对维生素 D 对内分泌系统各个方面的影响的理解也在加深。甲状旁腺功能亢进症（PHPT）是一种内分泌系统疾病，如果不能得到诊断，可能会导致虚弱。新的关于维生素 D 对甲状旁腺激素调节作用的理解可能为更好地理解 PHPT 和维生素 D 缺乏的共存提供机会。
一项基于证据的文献综述是基于对涉及维生素 D 和原发性甲状旁腺功能亢进症的文献的 PubMed 搜索，并对现有的维生素 D 研究进行评估。PubMed 搜索包括 1977 年至 2008 年发表的英文文章，重点是 2005 年至目前为止的研究和分析。本研究检查了最近在理解维生素 D 和 PHPT 之间关系方面的进展。对现有文献的回顾检查了维生素 D 不足和缺乏的影响，包括维生素 D 不足/缺乏诊断的影响、PHPT 的诊断和管理以及对整体健康的影响。证据水平根据 Sackett 等人提出的标准确定，推荐等级根据 Heinrich 等人提出的标准确定。
基于维生素 D/PHPT 的文献主要为 III 级和 IV 级证据，有几项值得注意的 Heinrich 级 A、B 和 C 研究。通过参考文献和章节进一步评估了研究的综述。
维生素 D 代谢在 PHPT 的病因、诊断和治疗中起着重要作用。对这两种情况的治疗可能对人类的整体健康有重要影响。
