Latorre F, Cassano P
Istituto Policattedra di Otorinolaringoiatria, Università di Bari.
Boll Soc Ital Biol Sper. 1991 Mar;67(3):319-26.
Nasal reactivity to histamine was evaluated in 40 normal subjects. The application of a chloride histamine solution (1 mg) registered in 90% of the subjects the appearance of sneezing with the number of sneezes ranging between one and fourteen (5.7 +/- 3.76) and an average increase in the total resistence in the inspiration phase of 93.1% (+/- 63.2) and in the expiration phase of 98.1% (+/- 60.5) with a range between 37.7% and 24.1%. The authors conclude that sneezing and above all nasal congestion evaluated rhinomanometrically represent two important parameters in the evaluation of nasal reaction; an increase greater than or equal to 200% of the total nasal resistance can surely be considered an index of nasal hyperreactivity.
对40名正常受试者进行了组胺鼻反应性评估。应用氯化组胺溶液（1毫克）后，90%的受试者出现打喷嚏，喷嚏次数在1至14次之间（5.7±3.76），吸气期总阻力平均增加93.1%（±63.2），呼气期增加98.1%（±60.5），范围在37.7%至241%之间。作者得出结论，通过鼻阻力测量评估的打喷嚏，尤其是鼻充血，是评估鼻反应的两个重要参数；总鼻阻力增加大于或等于200%肯定可被视为鼻高反应性的指标。
