Suppr超能文献

大学卫生系统联盟数据库中根治性肾切除术的手术结果:医院病例数量、医院规模和地理位置对40000名患者的影响。

Radical nephrectomy surgical outcomes in the University HealthSystem Consortium Data Base: Impact of hospital case volume, hospital size, and geographic location on 40,000 patients.

作者信息

Mitchell Robert E, Lee Byron T, Cookson Michael S, Barocas Daniel A, Duke Herrell S, Clark Peter E, Smith Joseph A, Chang Sam S

机构信息

Department of Urologic Surgery, Vanderbilt University, Nashville, Tennessee 37232, USA.

出版信息

Cancer. 2009 Jun 1;115(11):2447-52. doi: 10.1002/cncr.24292.

Abstract

BACKGROUND

We sought to determine the impact of radical nephrectomy case volume, hospital size, and geographic region on immediate surgical outcomes for patients undergoing radical nephrectomy in academic centers across the country.

METHODS

The University HealthSystem Consortium (UHC) Clinical Data Base was queried for data corresponding to patients who underwent radical nephrectomy at 1 of 134 academic medical centers nationwide between 2003 and quarter 2 of 2007 (n = 42,988). Radical nephrectomy case volume (1-99, 100-499, and 500 +), total discharges (1-49,999, 50,000-99,999, 100,000 +), and geographic region (5 categories) were determined for each academic center. ANOVA and the Tukey statistic were used. Length of stay, intensive care unit (ICU) rate, complication (comp) rate, and in-hospital mortality were analyzed.

RESULTS

Case volume was a significant predictor of length of stay, ICU, and comp. Mean length of stay was 6.88, 5.61, and 4.76 days, respectively, for centers from lowest to highest case volumes (P < .001). ICU rates for the 3 tiers were 30.77, 17.93, and 12.22 (P < .001). Comp rates were 24.50, 19.40, and 15.48 (P < .001). Tukey analysis revealed a ceiling effect: No differences were seen between the 2 higher case volume groups. Stratification by total discharges revealed differences in ICU rates (P = .001) and comp rates (P = .001). Region of the country had no significant impact on any of the outcome variables in this study.

CONCLUSIONS

Radical nephrectomy case volume emerged as an important variable in predicting 3 of the 4 outcome parameters in this study. Results suggest that a "critical volume" of cases portends improved surgical outcomes.

摘要

背景

我们试图确定根治性肾切除术的病例数量、医院规模和地理区域对全国学术中心接受根治性肾切除术患者的近期手术结局的影响。

方法

查询大学健康系统联盟(UHC)临床数据库,获取2003年至2007年第二季度期间在全国134个学术医疗中心之一接受根治性肾切除术的患者的数据(n = 42,988)。确定每个学术中心的根治性肾切除术病例数量(1 - 99、100 - 499和500 +)、总出院人数(1 - 49,999、50,000 - 99,999、100,000 +)以及地理区域(5个类别)。使用方差分析和Tukey统计量。分析住院时间、重症监护病房(ICU)使用率、并发症发生率和住院死亡率。

结果

病例数量是住院时间、ICU使用率和并发症发生率的重要预测因素。病例数量从低到高的中心,平均住院时间分别为6.88天、5.61天和4.76天(P <.001)。三个层级的ICU使用率分别为30.77、17.93和12.22(P <.001)。并发症发生率分别为24.50、19.40和15.48(P <.001)。Tukey分析显示存在天花板效应:两个较高病例数量组之间未观察到差异。按总出院人数分层显示ICU使用率(P =.001)和并发症发生率(P =.001)存在差异。该国的地区对本研究中的任何结局变量均无显著影响。

结论

根治性肾切除术病例数量是本研究中四个结局参数中三个的重要预测变量。结果表明,病例的“临界数量”预示着手术结局的改善。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验