在巴西东南部进行的一项为期4年的研究中，人偏肺病毒的流行病学和基因变异性。
Epidemiology and genetic variability of human metapneumovirus during a 4-year-long study in Southeastern Brazil.
作者信息
Oliveira Danielle B L, Durigon Edison L, Carvalho Ariane C L, Leal Andréa L, Souza Thereza S, Thomazelli Luciano M, Moraes Claudia T P, Vieira Sandra E, Gilio Alfredo E, Stewien Klaus E
机构信息
Department of Microbiology, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil.
出版信息
J Med Virol. 2009 May;81(5):915-21. doi: 10.1002/jmv.21436.
Epidemiological and molecular characteristics of human metapneumovirus (hMPV) were compared with human respiratory syncytial virus (hRSV) in infants and young children admitted for acute lower respiratory tract infections in a prospective study during four consecutive years in subtropical Brazil. GeneScan polymerase chain assays (GeneScan RT-PCR) were used to detect hMPV and hRSV in nasopharyngeal aspirates of 1,670 children during January 2003 to December 2006. hMPV and hRSV were detected, respectively, in 191 (11.4%) and in 702 (42%) of the children admitted with acute lower respiratory tract infections at the Sao Paulo University Hospital. Sequencing data of the hMPV F gene revealed that two groups of the virus, each divided into two subgroups, co-circulated during three consecutive years. It was also shown that a clear dominance of genotype B1 occurred during the years 2004 and 2005, followed by genotype A2 during 2006.
在巴西亚热带地区进行的一项为期四年的前瞻性研究中，对因急性下呼吸道感染入院的婴幼儿，比较了人偏肺病毒（hMPV）和人呼吸道合胞病毒（hRSV）的流行病学及分子特征。2003年1月至2006年12月期间，采用基因扫描聚合酶链反应检测法（GeneScan RT-PCR），对1670名儿童的鼻咽抽吸物进行了hMPV和hRSV检测。圣保罗大学医院收治的急性下呼吸道感染儿童中，分别有191名（11.4%）和702名（42%）检测出hMPV和hRSV。hMPV F基因测序数据显示，该病毒的两组各分为两个亚组，在连续三年中共同流行。还表明，2004年和2005年B1基因型明显占优势，随后2006年A2基因型占优势。
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