Santos A T
Southeast Asian J Trop Med Public Health. 1976 Jun;7(2):306-9.
For the past several decades, the drug being used for the treatment of schistosomiasis in the Philippines has been Stibophen. It is administered intramuscularly at a dose of 1 ml per 10 kg body weight with a maximum of 5 ml every other day after 2 initial daily smaller sensitivity doses at a total dose of 45 to 70 ml fof adult patients. In recent years, a number of drugs for the treatment of schistosomiasis have been developed. These were evaluated clinically either in the hospital or in field trials in Leyte. Unfortunately, none of these were found to be suitable for mass treatment on account of toxicity to prolonged course of treatment. In view of the pressing need for a safe and effective schistosomicidal agent, the search for a better drug is imperative.
在过去几十年里，菲律宾用于治疗血吸虫病的药物一直是锑波芬。成人患者最初每日给予较小的敏感剂量，之后每隔一天肌肉注射，剂量为每10公斤体重1毫升，最大剂量为5毫升，总剂量为45至70毫升。近年来，已研发出多种治疗血吸虫病的药物。这些药物在医院或莱特岛的现场试验中进行了临床评估。不幸的是，由于毒性或治疗疗程过长，这些药物均不适合大规模治疗。鉴于迫切需要一种安全有效的杀血吸虫剂，寻找更好的药物势在必行。
