Ricco Rosalia, Dalena Anna Maria, Valente Tiziana, Lettini Teresa, Sanguedolce Francesca, Delfino Antonella R Pesce
Department of Anatomic Pathology, University of Bari, Bari Italy.
Anal Quant Cytol Histol. 2009 Feb;31(1):41-8.
To assess the relationship between morphologic features of placental villi and the occurrence of trisomy.
We selected 9 placentas with genetically diagnosed trisomy 21 and 6 normal placentas of matched gestational age. The 150 selected villi underwent a morphometric study using the Shape Analytical Morphometry system, availing itself of an ordinary section to study dimensions and of a specific section to study the shape. The analytic morphometric procedure for shape analysis consisted of 3 steps: upper degree polynomial equations, Fourier analysis and parabolic fitting.
Trisomic villi showed bigger size and a more asymmetric and irregular shape than did normal villi.
We believe that this method can provide valuable information and that further studies are needed to analyze more cohorts of pathologic villi, thus providing a complete pattern of morphologic aberrations related to each placental disease.
评估胎盘绒毛的形态学特征与三体发生之间的关系。
我们选取了9个经基因诊断为21三体的胎盘以及6个孕周匹配的正常胎盘。使用形状分析形态测量系统对选取的150个绒毛进行形态测量研究，利用普通切片研究尺寸，利用特定切片研究形状。形状分析的解析形态测量程序包括3个步骤：高阶多项式方程、傅里叶分析和抛物线拟合。
三体绒毛比正常绒毛尺寸更大，形状更不对称且不规则。
我们认为该方法能够提供有价值的信息，并且需要进一步研究以分析更多病理绒毛队列，从而提供与每种胎盘疾病相关的完整形态学畸变模式。
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