抑制成体神经发生会导致下丘脑-垂体-肾上腺轴反应增强。
Suppression of adult neurogenesis leads to an increased hypothalamo-pituitary-adrenal axis response.
作者信息
Schloesser Robert J, Manji Husseini K, Martinowich Keri
机构信息
Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-3711, USA.
出版信息
Neuroreport. 2009 Apr 22;20(6):553-7. doi: 10.1097/WNR.0b013e3283293e59.
Abstract
Stress and glucocorticoids are among the strongest inhibitors of adult hippocampal neurogenesis. Despite the known role of the hippocampus in negative feedback regulation of the hypothalamo-pituitary-adrenal axis, whether the loss of hippocampal neurogenesis affects this inhibition has not been examined. Here we tested whether suppression of adult neurogenesis affected the hypothalamo-pituitary-adrenal axis response. Our results show that suppression of neurogenesis leads to a potentiated hypothalamo-pituitary-adrenal axis response after an exposure to a mild stressor. This study suggests that suppressed neurogenesis regulates the hypothalamo-pituitary-adrenal axis response.
摘要
应激和糖皮质激素是成年海马神经发生最强的抑制剂。尽管已知海马体在下丘脑-垂体-肾上腺轴的负反馈调节中发挥作用，但海马神经发生的丧失是否会影响这种抑制作用尚未得到研究。在此，我们测试了成年神经发生的抑制是否会影响下丘脑-垂体-肾上腺轴的反应。我们的结果表明，神经发生的抑制会导致在暴露于轻度应激源后下丘脑-垂体-肾上腺轴反应增强。这项研究表明，受抑制的神经发生调节下丘脑-垂体-肾上腺轴反应。
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