人溶菌酶淀粉样原纤维诱导红细胞和脂质囊泡聚集。
Hen lysozyme amyloid fibrils induce aggregation of erythrocytes and lipid vesicles.
作者信息
Chaudhary Nitin, Nagaraj Ramakrishnan
机构信息
Centre for Cellular and Molecular Biology, Hyderabad, India.
出版信息
Mol Cell Biochem. 2009 Aug;328(1-2):209-15. doi: 10.1007/s11010-009-0091-8. Epub 2009 Mar 26.
PMID:19322639
Abstract
We have studied the interaction of hen egg white lysozyme (HEWL) amyloid fibrils with human erythrocytes and lipid vesicles. The fibrils caused extensive aggregation of human erythrocytes and lipid vesicles without any significant lysis. The membrane activity of HEWL fibrils suggests that the interaction of lysozyme fibrils with cellular membranes could be a contributing factor under disease conditions.
摘要
我们研究了鸡蛋清溶菌酶（HEWL）淀粉样纤维与人类红细胞和脂质囊泡的相互作用。这些纤维导致人类红细胞和脂质囊泡大量聚集，且无明显裂解。HEWL纤维的膜活性表明，溶菌酶纤维与细胞膜的相互作用可能是疾病状态下的一个促成因素。
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