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人溶菌酶淀粉样原纤维诱导红细胞和脂质囊泡聚集。

Hen lysozyme amyloid fibrils induce aggregation of erythrocytes and lipid vesicles.

作者信息

Chaudhary Nitin, Nagaraj Ramakrishnan

机构信息

Centre for Cellular and Molecular Biology, Hyderabad, India.

出版信息

Mol Cell Biochem. 2009 Aug;328(1-2):209-15. doi: 10.1007/s11010-009-0091-8. Epub 2009 Mar 26.

DOI:10.1007/s11010-009-0091-8
PMID:19322639
Abstract

We have studied the interaction of hen egg white lysozyme (HEWL) amyloid fibrils with human erythrocytes and lipid vesicles. The fibrils caused extensive aggregation of human erythrocytes and lipid vesicles without any significant lysis. The membrane activity of HEWL fibrils suggests that the interaction of lysozyme fibrils with cellular membranes could be a contributing factor under disease conditions.

摘要

我们研究了鸡蛋清溶菌酶（HEWL）淀粉样纤维与人类红细胞和脂质囊泡的相互作用。这些纤维导致人类红细胞和脂质囊泡大量聚集，且无明显裂解。HEWL纤维的膜活性表明，溶菌酶纤维与细胞膜的相互作用可能是疾病状态下的一个促成因素。

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本文引用的文献

1
Binding of lysozyme to phospholipid bilayers: evidence for protein aggregation upon membrane association.溶菌酶与磷脂双层的结合：膜结合时蛋白质聚集的证据。
Biophys J. 2007 Jul 1;93(1):140-53. doi: 10.1529/biophysj.106.102749. Epub 2007 Apr 13.
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Lysozyme amyloid oligomers and fibrils induce cellular death via different apoptotic/necrotic pathways.溶菌酶淀粉样寡聚体和原纤维通过不同的凋亡/坏死途径诱导细胞死亡。
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Normal and aberrant biological self-assembly: Insights from studies of human lysozyme and its amyloidogenic variants.
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Intermediate amyloid oligomers of lysozyme: Is their cytotoxicity a particular case or general rule for amyloid?溶菌酶的中间淀粉样寡聚体：它们的细胞毒性是淀粉样蛋白的特殊情况还是普遍规律？
Biochemistry (Mosc). 2006 May;71(5):505-12. doi: 10.1134/s0006297906050063.
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Cytotoxicity of albebetin oligomers depends on cross-beta-sheet formation.阿尔贝贝汀寡聚体的细胞毒性取决于交叉β-折叠的形成。
FEBS Lett. 2006 May 1;580(10):2451-7. doi: 10.1016/j.febslet.2006.03.074. Epub 2006 Apr 7.
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Evidence that Perutz's double-beta-stranded subunit structure for beta-amyloids also applies to their channel-forming structures in membranes.有证据表明，佩鲁茨提出的β-淀粉样蛋白的双β链亚基结构也适用于它们在膜中的通道形成结构。
Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1546-50. doi: 10.1073/pnas.0509892103. Epub 2006 Jan 23.
7
Amyloid-beta peptide disruption of lipid membranes and the effect of metal ions.β-淀粉样肽对脂质膜的破坏作用及金属离子的影响
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8
Islet amyloid polypeptide inserts into phospholipid monolayers as monomer.胰岛淀粉样多肽以单体形式插入磷脂单分子层。
J Mol Biol. 2006 Feb 24;356(3):783-9. doi: 10.1016/j.jmb.2005.12.020. Epub 2005 Dec 21.
9
Interaction of human stefin B in the prefibrillar oligomeric form with membranes. Correlation with cellular toxicity.人源前纤维寡聚体形式的丝氨酸蛋白酶抑制剂B与膜的相互作用。与细胞毒性的相关性。
FEBS J. 2005 Jun;272(12):3042-51. doi: 10.1111/j.1742-4658.2005.04717.x.
10
Raft lipids as common components of human extracellular amyloid fibrils.筏脂作为人类细胞外淀粉样纤维的常见成分。
Proc Natl Acad Sci U S A. 2005 May 3;102(18):6297-302. doi: 10.1073/pnas.0407035102. Epub 2005 Apr 25.