钯催化芳基卤化物与氨的一般胺化反应。

A general palladium-catalyzed amination of aryl halides with ammonia.

作者信息

Schulz Thomas, Torborg Christian, Enthaler Stephan, Schäffner Benjamin, Dumrath Andreas, Spannenberg Anke, Neumann Helfried, Börner Armin, Beller Matthias

机构信息

Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Strasse 29a, 18059 Rostock, Germany.

出版信息

Chemistry. 2009;15(18):4528-33. doi: 10.1002/chem.200802678.

DOI:10.1002/chem.200802678

PMID:19322847

Abstract

A new robust palladium/phosphine catalyst system for the selective monoarylation of ammonia with different aryl bromides and chlorides has been developed. The active catalyst is formed in situ from [Pd(OAc)(2)] and air- and moisture-stable phosphines as easy-to-handle pre-catalysts. The productivity of the catalyst system is comparable to that of competitive Pd/phosphine systems; full conversion is achieved with most substrates with 1-2 mol % of Pd source and a fourfold excess of ligand (L).

摘要

已开发出一种新型的稳健钯/膦催化剂体系，用于不同芳基溴化物和氯化物与氨的选择性单芳基化反应。活性催化剂由[Pd(OAc)₂]和对空气和湿气稳定的膦原位形成，作为易于操作的预催化剂。该催化剂体系的产率与竞争性钯/膦体系相当；大多数底物使用1-2 mol%的钯源和四倍过量的配体（L）即可实现完全转化。