Jafri Wasim, Subhan Amna
Department of Medicine, Aga Khan University, P.O. Box 3500, Stadium Road, Karachi - 74800, Pakistan.
Trop Gastroenterol. 2008 Oct-Dec;29(4):194-201.
Hepatitis C virus is one of the most common blood-borne viruses and is associated with significant morbidity and mortality. It affects 170 million people worldwide and 2.4%-6.5% people in Pakistan. Therapeutic injections by contaminated, re-used syringes, transfusion of unsafe blood and re-use of razors are major factors responsible for the spread of hepatitis C in the general population. Genotype 3 is the most common genotype in Pakistan and is most responsive to interferon and ribavirin combination therapy. HCV is the leading cause of chronic liver disease and hepatocellular carcinoma in Pakistan. Appropriate steps need to be taken in the country to control factors responsible for the spread of hepatitis C.
丙型肝炎病毒是最常见的血源病毒之一，与严重的发病率和死亡率相关。全球有1.7亿人感染该病毒，巴基斯坦的感染率为2.4%-6.5%。使用受污染的重复使用注射器进行治疗性注射、不安全血液输血以及重复使用剃须刀是丙型肝炎在普通人群中传播的主要因素。3型基因型是巴基斯坦最常见的基因型，对干扰素和利巴韦林联合疗法反应最为敏感。在巴基斯坦，丙肝病毒是慢性肝病和肝细胞癌的主要病因。该国需要采取适当措施来控制导致丙肝传播的因素。
