在母婴分离期间，抗炎作用对行为反应有影响，但对皮质醇反应无影响。
Anti-inflammatory influences on behavioral, but not cortisol, responses during maternal separation.
作者信息
Perkeybile Allison M, Schiml-Webb Patricia A, O'Brien Erin, Deak Terrence, Hennessy Michael B
机构信息
Department of Psychology, 335 Fawcett Hall, Wright State University, Dayton, OH 45435, United States.
出版信息
Psychoneuroendocrinology. 2009 Aug;34(7):1101-8. doi: 10.1016/j.psyneuen.2009.02.014. Epub 2009 Mar 25.
Abstract
The present study examined the effect of anti-inflammatory agents on the behavioral and plasma cortisol responses of guinea pig pups during isolation in a novel environment. In Experiment 1, intracerebroventricular (i.c.v.) administration of interleukin-10 (IL-10), across a range of doses, significantly reduced passive behaviors of isolated pups. In Experiment 2, neither i.c.v. IL-10 nor alpha-melanocyte stimulating hormone affected the plasma cortisol response to the separation procedure. These results provide further evidence that the passive behaviors of isolated guinea pig pups are mediated by proinflammatory cytokines and indicate that cytokines do not affect behavior indirectly by means of an action on hypothalamic-pituitary-adrenal activity.
摘要
本研究考察了抗炎药对豚鼠幼崽在新环境中隔离期间行为及血浆皮质醇反应的影响。在实验1中，脑室内注射不同剂量的白细胞介素-10（IL-10）可显著减少隔离幼崽的被动行为。在实验2中，脑室内注射IL-10和α-黑素细胞刺激素均未影响血浆皮质醇对分离程序的反应。这些结果进一步证明，隔离豚鼠幼崽的被动行为由促炎细胞因子介导，表明细胞因子不会通过作用于下丘脑-垂体-肾上腺活动间接影响行为。
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