Chapdelaine J M, Whalen J D, Wooley P H
Department of Internal Medicine, Wayne State University Medical School, Detroit, MI 48201.
Autoimmunity. 1991;8(3):215-20. doi: 10.3109/08916939108997109.
Pristane-induced arthritis was investigated in DBA/1, DBA/2, and BALB/c mice, and F1 hybrid mice generated from inter-crosses between these strains. The incidence of disease in F1 hybrid mice was significantly lower than the susceptible parental strains (DBA/1 and BALB/c), and resistance to arthritis was observed in both DBA/2 mice and the (DBA/2 x BALB/c) F1 hybrid mice. Several cellular immune abnormalities were observed in pristane-injected DBA/1 mice. Con A mitogen responses were depressed following pristane injection, and a functional suppressor cell population was detected. Delayed type hypersensitivity responses to type II collagen were observed in pristane injected mice. The intraperitoneal injection of pristane appears to alter immune regulation and induce autoimmune responses to connective tissue components.
在DBA/1、DBA/2和BALB/c小鼠以及由这些品系间杂交产生的F1杂种小鼠中研究了 pristane诱导的关节炎。F1杂种小鼠的疾病发生率显著低于易感亲本品系（DBA/1和BALB/c），并且在DBA/2小鼠和（DBA/2×BALB/c）F1杂种小鼠中均观察到对关节炎的抗性。在注射pristane的DBA/1小鼠中观察到几种细胞免疫异常。注射pristane后Con A丝裂原反应受到抑制，并检测到功能性抑制细胞群。在注射pristane的小鼠中观察到对II型胶原的迟发型超敏反应。腹腔注射pristane似乎会改变免疫调节并诱导对结缔组织成分的自身免疫反应。
