New Crops and Processing Technology Research Unit, National Center for Agricultural Utilization Research, Agricultural Research Service, United States Department of Agriculture, 1815 N. University Street, Peoria, IL 61604, USA.
Int J Mol Sci. 2008 Apr;9(4):498-511. doi: 10.3390/ijms9040498. Epub 2008 Apr 4.
Quartz crystal microbalance with dissipation (QCM-D) monitoring and atomic force microscopy (AFM) were combined to evaluate the defects created by an ionic liquid anion and a cation in a supported phospholipid bilayer composed of zwitterionic lipids on a silica surface. The cation 1-octyl-3-methyl imidazolium (OMIM(+)) was shown to remove lipids from the bilayer, increase the roughness to approximately 2.8 nm (~0.2 for stable supported bilayer) and possibly redeposit lipids with entrapped water. The anion bis(trifluoromethylsulfonyl)imide (Tf(2)N(-)) was found to leave distinct defects within the bilayer that had large pore-like interiors which left the surrounding bilayer intact. However, the ionic liquid 1-butyl-1-methyl pyrrolidinium bis(trifluoromethylsulfonyl)imide (BMP-Tf(2)N) formed a film over the supported bilayer. This work demonstrates, for the first time, the direct effects common components of ionic liquids have on a supported phospholipids bilayer.
采用石英晶体微天平（QCM-D）监测和原子力显微镜（AFM）相结合的方法，研究了在二氧化硅表面的两性离子脂质组成的支撑磷脂双层中，离子液体的阴离子和阳离子所产生的缺陷。结果表明，阳离子 1-辛基-3-甲基咪唑鎓（OMIM(+)）可以从双层中去除脂质，使粗糙度增加到约 2.8nm（稳定支撑双层时约为 0.2nm），并可能与夹带水的脂质重新沉积。阴离子双（三氟甲烷磺酰基）亚胺（Tf(2)N(-)）则被发现会在双层内留下明显的缺陷，这些缺陷具有大的类孔状内部，使周围的双层保持完整。然而，离子液体 1-丁基-1-甲基吡咯烷双（三氟甲烷磺酰基）亚胺（BMP-Tf(2)N）则在支撑磷脂双层上形成了一层膜。这项工作首次证明了离子液体常见成分对支撑磷脂双层的直接影响。
Zotero 插件
