造血干细胞：在细胞凋亡与自我更新之间
The haemopoietic stem cell: between apoptosis and self renewal.
作者信息
Alenzi Faris Q, Alenazi Badi Q, Ahmad Shamweel Y, Salem Mohamed L, Al-Jabri Ali A, Wyse Richard K H
机构信息
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Saudi Arabia.
出版信息
Yale J Biol Med. 2009 Mar;82(1):7-18.
Abstract
Self renewal and apoptosis of haemopoietic stem cells (HSC) represent major factors that determine the size of the haemopoietic cell mass. Changes in self renewal above or below the steady state value of 0.5 will result in either bone marrow expansion or aplasia, respectively. Despite the growing body of research that describes the potential role of HSC, there is still very little information on the mechanisms that govern HSC self renewal and apoptosis. Considerable insight into the role of HSC in many diseases has been gained in recent years. In light of their crucial importance, this article reviews recent developments in the understanding of the molecular, biological, and physiological characteristics of haemopoietic stem cells.
摘要
造血干细胞（HSC）的自我更新和凋亡是决定造血细胞数量的主要因素。自我更新高于或低于稳态值0.5的变化将分别导致骨髓扩张或发育不全。尽管描述造血干细胞潜在作用的研究越来越多，但关于调控造血干细胞自我更新和凋亡机制的信息仍然很少。近年来，人们对造血干细胞在许多疾病中的作用有了相当深入的了解。鉴于其至关重要性，本文综述了造血干细胞分子、生物学和生理学特征理解方面的最新进展。
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本文引用的文献
1
FoxO3a regulates hematopoietic homeostasis through a negative feedback pathway in conditions of stress or aging.
Blood. 2008 Dec 1;112(12):4485-93. doi: 10.1182/blood-2008-05-159848. Epub 2008 Sep 17.
2
Telomeres and telomerase in stem cells during aging and disease.
Genome Dyn. 2006;1:84-103. doi: 10.1159/000092502.
3
Regulation of reactive oxygen species and genomic stability in hematopoietic stem cells.
Antioxid Redox Signal. 2008 Nov;10(11):1883-94. doi: 10.1089/ars.2008.2114.
4
Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival.
J Immunol. 2008 Jun 1;180(11):7358-67. doi: 10.4049/jimmunol.180.11.7358.
5
Replicative stress, stem cells and aging.
Mech Ageing Dev. 2008 Jul-Aug;129(7-8):460-6. doi: 10.1016/j.mad.2008.03.009. Epub 2008 Mar 28.
6
Stem cells and the rate of living.
Cell Stem Cell. 2007 Jun 7;1(1):9-11. doi: 10.1016/j.stem.2007.05.004.
7
Expression of Fas and Fas-ligand in donor hematopoietic stem and progenitor cells is dissociated from the sensitivity to apoptosis.
Exp Hematol. 2007 Oct;35(10):1601-12. doi: 10.1016/j.exphem.2007.07.010.
8
Fas transduces dual apoptotic and trophic signals in hematopoietic progenitors.
Stem Cells. 2007 Dec;25(12):3194-203. doi: 10.1634/stemcells.2007-0402. Epub 2007 Sep 13.
9
Life and death in hematopoietic stem cells.
Curr Opin Immunol. 2007 Oct;19(5):503-9. doi: 10.1016/j.coi.2007.05.001. Epub 2007 Jul 6.
10
Hematopoiesis and thymic apoptosis are not affected by the loss of Cdk2.
Mol Cell Biol. 2007 Jul;27(14):5079-89. doi: 10.1128/MCB.00029-07. Epub 2007 May 7.
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