Navarro Pablo, Avner Philip
Institut Pasteur, Unité de Génétique Moléculaire Murine, CNRS, URA2578, F-75015 Paris, France.
FEBS Lett. 2009 Jun 5;583(11):1721-7. doi: 10.1016/j.febslet.2009.03.043. Epub 2009 Mar 25.
The integration of X-inactivation with development is a crucial aspect of this classical paradigm of epigenetic regulation. During early female mouse development, X-inactivation reprogramming occurs in pluripotent cells of the inner cell mass of the blastocyst and in pluripotent primordial germ cells. Here we discuss the developmental strategies which ensure the coupling of the regulation of X-inactivation to the acquisition of pluripotency through the regulation of the master of X-inactivation, the non-coding Xist gene, by the key factors which support pluripotency Nanog, Oct4 and Sox2.
X染色体失活与发育的整合是这种经典表观遗传调控模式的关键方面。在雌性小鼠早期发育过程中，X染色体失活重编程发生在囊胚内细胞团的多能细胞以及多能原始生殖细胞中。在此，我们讨论通过支持多能性的关键因子Nanog、Oct4和Sox2对X染色体失活的主控因子——非编码Xist基因进行调控，从而确保X染色体失活调控与多能性获得相耦合的发育策略。
