Rosengard S
J Int Med Res. 1977;5(3):199-206. doi: 10.1177/030006057700500310.
One hundred and forty-seven patients with essential hypertension participated in this multicentre study. The results indicate that metoprolol in a dosage of 150-450 mg daily is an effective and well tolerated therapy both in patients previously untreated and in patients unsatisfactorily treated with other antihypertensive agents.
147例原发性高血压患者参与了这项多中心研究。结果表明,美托洛尔每日剂量150 - 450毫克,对于既往未接受治疗的患者以及使用其他抗高血压药物治疗效果不佳的患者而言,都是一种有效且耐受性良好的治疗方法。