Vu An T, Cohn Stephen T, Terefenko Eugene A, Moore William J, Zhang Puwen, Mahaney Paige E, Trybulski Eugene J, Goljer Igor, Dooley Rebecca, Bray Jenifer A, Johnston Grace H, Leiter Jennifer, Deecher Darlene C
Chemical and Screening Sciences, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA.
Bioorg Med Chem Lett. 2009 May 1;19(9):2464-7. doi: 10.1016/j.bmcl.2009.03.054. Epub 2009 Mar 18.
A series of 3-(arylamino)-3-phenylpropan-2-olamines was prepared and screened for their ability to inhibit monoamine reuptake. A number of analogues displayed significant dual norepinephrine and serotonin reuptake inhibition. Compounds in this class exhibited minimal affinity for the dopamine transporter.