奥卡西平和丙戊酸治疗大鼠所致的视网膜神经节细胞毒性
Retinal ganglion cell toxicity due to oxcarbazepine and valproic acid treatment in rat.
作者信息
Aktaş Zeynep, Cansu Ali, Erdoğan Deniz, Take Gülnur, Goktas Guleser, Ozdek Sengul, Serdaroglu Ayse
机构信息
Department of Ophthalmology, Gazi University School of Medicine, Turkey.
出版信息
Seizure. 2009 Jul;18(6):396-9. doi: 10.1016/j.seizure.2009.02.003. Epub 2009 Mar 28.
PURPOSE
To evaluate and to compare the possible toxic effects of oxcarbazepine (OXC) and valproic acid (VPA) on retinal ganglion cells (RGCs) in rat.
METHODS
Forty female Wistar rats (21-24 days old and weighted between 44.6 and 57.3g) were divided equally into 4 experimental groups which were applied tap water (group 1), 300mg/(kgday) VPA (group 2), 100mg/(kgday) OXC (group 3), and both VPA and OXC (group 4) via gavage for 90 days. Enucleation was performed for histopathologic analysis. RGCs were counted under the light microscopic examination.
RESULTS
RGC numbers in OXC and combined OXC-VPA groups were found to be lower than those of control group. On the other hand RGC number was comparable with those of control group in VPA group.
CONCLUSION
OXC seems to be toxic to RGCs at 100mg/kg dose when it is been given as a monotherapy or combined with VPA. Single VPA treatment has no effect on RGC number.
目的
评估并比较奥卡西平（OXC）和丙戊酸（VPA）对大鼠视网膜神经节细胞（RGCs）可能产生的毒性作用。
方法
将40只雌性Wistar大鼠（21 - 24日龄，体重44.6至57.3克）平均分为4个实验组，分别通过灌胃给予自来水（第1组）、300毫克/（千克·天）的VPA（第2组）、100毫克/（千克·天）的OXC（第3组），以及VPA和OXC联合用药（第4组），持续90天。进行眼球摘除术以进行组织病理学分析。在光学显微镜检查下对RGCs进行计数。
结果
发现OXC组和OXC - VPA联合用药组的RGC数量低于对照组。另一方面，VPA组的RGC数量与对照组相当。
结论
当以100毫克/千克的剂量单独给药或与VPA联合给药时，OXC似乎对RGCs有毒性。单独使用VPA治疗对RGC数量没有影响。
Zotero 插件