Diler Durgut Betul, Turk Adem, Acar Arslan Elif, Kamasak Tulay, Sahin Sevim, Dilber Beril, Turkcan Soguksulu Tugce, Cansu Ali
Faculty of Medicine, Department of Child Neurology, Karadeniz Technical University, Trabzon, Turkey.
Faculty of Medicine, Department of Ophthalmology, Karadeniz Technical University, Trabzon, Turkey.
Childs Nerv Syst. 2019 May;35(5):769-774. doi: 10.1007/s00381-019-04076-5. Epub 2019 Feb 20.
To investigate the potential toxic effects of levetiracetam monotherapy on ocular tissues in cases of pediatric epilepsy using optical coherence tomography (OCT).
Thirty epileptic children (group 1) receiving levetiracetam monotherapy at a dosage of 20-40 mg/kg/day for at least 1 year with a first diagnosis of epilepsy and 30 age- and gender-matched healthy children (group 2) were included in the study. In addition to a detailed eye examination, peripapillary retinal nerve fiber layer (RNFL) thickness, ganglion cell complex (GCC) thickness, foveal thickness (FT), and central corneal thickness (CCT) were measured in all children by means of spectral domain OCT. The data obtained from the two groups were then subjected to statistical analysis.
The mean age of both groups was 12 ± 3.64 years [1-12]. The mean duration of levetiracetam in group 1 was 24.07 ± 12.82 months. Mean RNFL values in groups 1 and 2 were 106.1 ± 10.42 and 104.98 ± 10.04 μm, mean GCC values were 94.72 ± 6.26 and 94.4 ± 6 μm, mean FT values were 240.73 ± 17.94 and 240.77 ± 15.97 μm, and mean CCT values were 555.1 ± 44.88 and 540.97 ± 32.65 μm, respectively. No significant difference was determined between the two groups in terms of any parameter. Best corrected visual acuity values of the subjects in both groups were 10/10, and no color vision or visual field deficit was determined.
Levetiracetam monotherapy causes no significant function or morphological change in ocular tissues in pediatric epilepsies.
采用光学相干断层扫描（OCT）研究左乙拉西坦单药治疗对小儿癫痫患者眼部组织的潜在毒性作用。
本研究纳入30例首次诊断为癫痫且接受左乙拉西坦单药治疗（剂量为20 - 40mg/kg/天，至少1年）的癫痫患儿（第1组）和30例年龄及性别匹配的健康儿童（第2组）。除详细的眼部检查外，所有儿童均通过光谱域OCT测量视乳头周围视网膜神经纤维层（RNFL）厚度、神经节细胞复合体（GCC）厚度、黄斑中心凹厚度（FT）和中央角膜厚度（CCT）。然后对两组获得的数据进行统计分析。
两组的平均年龄均为12±3.64岁[1 - 12岁]。第1组左乙拉西坦的平均治疗时长为24.07±12.82个月。第1组和第2组的平均RNFL值分别为106.1±10.42μm和104.98±10.04μm，平均GCC值分别为94.72±6.26μm和94.4±6μm，平均FT值分别为240.73±17.94μm和240.77±15.97μm，平均CCT值分别为555.1±44.88μm和540.97±3,2.65μm。两组在任何参数方面均未发现显著差异。两组受试者的最佳矫正视力值均为10/10，且未发现色觉或视野缺损。
左乙拉西坦单药治疗对小儿癫痫患者的眼部组织未引起明显的功能或形态学改变。
