Orthopaedic Research Laboratory, Orthopedic Department, Spine Section E, Institute of Experimental Clinical Research, Aarhus University Hospital, Aarhus, Denmark.
Int Orthop. 2010 Mar;34(3):447-51. doi: 10.1007/s00264-009-0759-4. Epub 2009 Mar 28.
The bone-screw interface has been indicated as the weak link in pedicle screw spine fixation. Bisphosphonate treatment may have the effect of improving bone-screw interface fixation in spine fusion by inhibiting bone resorption. An experimental study was conducted using a porcine model to evaluate the influence of alendronate treatment on bone-pedicle screw interface fixation. Eleven pigs in the treatment group received alendronate 10 mg/day orally for three months postoperatively. The other 11 pigs served as a control group. Posterior lateral fusion with the CD Horizon pedicle screw system was performed with autograft on the lumbar spine on all animals. Biomechanical torsion test and histomorphometric parameters of screw fixation were evaluated three months after the operation. The maximum torque and initial angular stiffness of the treatment group was higher than that of the control group, but there was no statistical significance. The bone-screw contact surface was 23.3 +/- 10% for the treatment group and 9.8 +/- 5.9% for the control group (P < 0.01). This study indicated that alendronate treatment increased bone purchase of stainless steel screw surfaces.
骨螺钉界面已被认为是脊柱固定中经皮螺钉的薄弱环节。双磷酸盐治疗可能通过抑制骨吸收而改善脊柱融合中的骨螺钉界面固定。本研究采用猪模型进行了一项实验研究，以评估阿仑膦酸钠治疗对骨-螺钉界面固定的影响。实验组 11 头猪术后每天口服阿仑膦酸钠 10mg，共 3 个月。另 11 头猪作为对照组。所有动物均在腰椎后路进行侧外侧融合，使用自体移植物。术后 3 个月，进行生物力学扭转试验和螺钉固定的组织形态计量学参数评估。实验组的最大扭矩和初始角刚度高于对照组，但无统计学意义。实验组的骨-螺钉接触面积为 23.3 +/- 10%，对照组为 9.8 +/- 5.9%（P < 0.01）。本研究表明，阿仑膦酸钠治疗增加了不锈钢螺钉表面的骨量。
