Hidaka Toshikazu, Hama Seiji, Shrestha Prabin, Saito Taiichi, Kajiwara Yoshinori, Yamasaki Fumiyuki, Sugiyama Kazuhiko, Kurisu Kaoru
Department of Neurosurgery, Graduate School of Biomedical Sciences, Hiroshima University, Japan.
Anticancer Res. 2009 Feb;29(2):597-603.
The function of the cyclin-dependent kinase (cdk) inhibitor p27 is regulated by translocation between the nucleus (activate) and the cytosol (inactivate). No previous reports have examined the subcellular localization of p27 in glioma which was evaluated here regarding the prognosis in high-grade astrocytomas.
The pattern of subcellular localization of p27 expression was examined immunohistochemically in 49 patients with high-grade astrocytoma who were over 20 years of age. The relationship between p27 localization and the prognosis was statistically examined.
Kaplan-Meier survival analysis showed that cytoplasmic p27 expression was statistically associated with a worse prognosis (p = 0.0203), while nuclear p27 expression showed some tendency towards a better prognosis (p = 0.1180). Cox multiple regression analysis showed the combination of high nuclear and low cytoplasmic p27 expression associated with a significantly better prognosis in high-grade astrocytoma.
A combination of low cytoplasmic and high nuclear expression of p27 predicts a better prognosis in high-grade astrocytomas and thus the subcellular localization of p27 expression is useful for predicting the prognosis for these patients.
细胞周期蛋白依赖性激酶（cdk）抑制剂p27的功能通过在细胞核（激活）和细胞质（失活）之间的转位来调节。以前没有报告研究过p27在胶质瘤中的亚细胞定位，本文对此进行了评估，以探讨其在高级别星形细胞瘤中的预后情况。
对49例年龄超过20岁的高级别星形细胞瘤患者进行免疫组织化学检查，以检测p27表达的亚细胞定位模式。对p27定位与预后之间的关系进行了统计学检验。
Kaplan-Meier生存分析表明，细胞质p27表达与较差的预后具有统计学相关性（p = 0.0203），而细胞核p27表达显示出一些预后较好的趋势（p = 0.1180）。Cox多元回归分析表明，高级别星形细胞瘤中高细胞核和低细胞质p27表达的组合与显著更好的预后相关。
p27低细胞质和高细胞核表达的组合预示着高级别星形细胞瘤的预后较好，因此p27表达的亚细胞定位有助于预测这些患者的预后。
