Tamaki Yasuhiro
Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan.
Nanomedicine (Lond). 2009 Apr;4(3):341-52. doi: 10.2217/nnm.09.10.
Polyion complex (PIC) micelles have a size range of tens of nanometers formed through electrostatic interaction. In experimental choroidal neovascularization (CNV) in rats, the PIC micelle accumulates to the CNV lesions and is retained. PIC micelles can be used for effective drug delivery to CNV. A novel dendritic photosensitizer encapsulated by a polymeric-micelle formulation was employed for an effective photodynamic therapy for age-related macular degeneration. With its highly selective accumulation on experimental CNV lesions, this treatment resulted in a remarkably efficacious CNV occlusion with minimal unfavorable phototoxicity. Gene therapy is a promising approach to treat age-related macular degeneration. A ternary complex, composed of a core containing DNA packaged with cationic peptides and enveloped in the anionic dendrimer phthalocyanine, has been developed, which provides the photosensitizing action. Subconjunctival injection of the ternary complex followed by laser irradiation resulted in transgene expression only in the laser-irradiated site in rats.
聚离子复合物（PIC）胶束通过静电相互作用形成，尺寸范围为几十纳米。在大鼠实验性脉络膜新生血管（CNV）中，PIC胶束会积聚到CNV病变处并留存。PIC胶束可用于向CNV有效递送药物。一种由聚合物胶束制剂包裹的新型树枝状光敏剂被用于对年龄相关性黄斑变性进行有效的光动力疗法。由于其在实验性CNV病变处具有高度选择性积聚，这种治疗方法以最小的不良光毒性实现了显著有效的CNV闭塞。基因治疗是治疗年龄相关性黄斑变性的一种有前景的方法。一种三元复合物已被研发出来，其核心由包裹着阳离子肽的DNA组成，并被阴离子树枝状酞菁包封，该复合物具有光敏作用。在大鼠结膜下注射三元复合物并随后进行激光照射，结果仅在激光照射部位出现转基因表达。
