van Vollenhoven Ronald F
Department of Rheumatology, Karolinska University Hospital, 17176 Stockholm, Sweden.
BMC Med. 2009 Mar 30;7:12. doi: 10.1186/1741-7015-7-12.
Sex differences in the prevalence of autoimmune diseases such as rheumatoid arthritis (RA) are well described, but the literature is not as clear about sex differences in RA disease course and prognosis. A recent study from a very large cross-sectional international cohort demonstrated slightly worse levels of disease activity and function in female patients with RA, compared with men. These findings are discussed in the context of our evolving knowledge of sex differences in the expression of this prototypic autoimmune disease, both in terms of the actual disease activity level, the effects that the disease has on physical function, and our ability accurately to measure these aspects.
类风湿关节炎（RA）等自身免疫性疾病患病率的性别差异已有充分描述，但关于RA疾病进程和预后的性别差异，文献阐述得并不清晰。最近一项来自一个非常大型的横断面国际队列研究表明，与男性相比，女性RA患者的疾病活动水平和功能略差。我们从实际疾病活动水平、疾病对身体功能的影响以及我们准确测量这些方面的能力等方面，在对这种典型自身免疫性疾病表达中的性别差异的认识不断发展的背景下讨论了这些发现。
