Horowitz Neil S, Goldstein Donald P, Berkowitz Ross S
New England Trophoblastic Disease Center, Brigham and Women's Hospital, Department of Obstetrics and Gynecology, Boston, MA 02115, USA.
Semin Oncol. 2009 Apr;36(2):181-9. doi: 10.1053/j.seminoncol.2008.12.009.
Molar pregnancy and gestational trophoblastic neoplasms (GTN) comprise a group of interrelated diseases with a varying degree of aggressiveness. Complete and partial molar pregnancy, invasive mole, placental site trophoblastic tumor (PSTT), and choriocarcinoma cover the spectrum of GTN. GTN is one of the few highly curable human tumors, even in the setting of advanced disease and widespread metastases. Although GTN typically follows a molar pregnancy, they can occur after any gestational event. This review discusses the basic principles of management and recent advances in the diagnosis and treatment of patients with GTN.
葡萄胎妊娠和妊娠滋养细胞肿瘤（GTN）是一组相互关联的疾病，其侵袭性程度各异。完全性和部分性葡萄胎妊娠、侵蚀性葡萄胎、胎盘部位滋养细胞肿瘤（PSTT）以及绒毛膜癌涵盖了GTN的范围。GTN是少数即使在疾病晚期和广泛转移情况下仍具有高治愈率的人类肿瘤之一。虽然GTN通常继发于葡萄胎妊娠，但也可发生于任何妊娠事件之后。本综述讨论了GTN患者管理的基本原则以及诊断和治疗方面的最新进展。
