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一项针对12至18个月大的泰国儿童,将纯化鸡胚细胞狂犬病疫苗通过肌肉注射或皮内注射,并同时接种日本脑炎疫苗的免疫原性、安全性和加强免疫反应的三年临床研究。

A three-year clinical study on immunogenicity, safety, and booster response of purified chick embryo cell rabies vaccine administered intramuscularly or intradermally to 12- to 18-month-old Thai children, concomitantly with Japanese encephalitis vaccine.

作者信息

Pengsaa Krisana, Limkittikul Kriengsak, Sabchareon Arunee, Ariyasriwatana Churdchoo, Chanthavanich Pornthep, Attanath Phanosri, Malerczyk Claudius

机构信息

Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

出版信息

Pediatr Infect Dis J. 2009 Apr;28(4):335-7. doi: 10.1097/INF.0b013e3181906351.

DOI:10.1097/INF.0b013e3181906351
PMID:19333080
Abstract

After concomitant administration of purified chick embryo cell rabies vaccine and Japanese encephalitis vaccine to toddlers, adequate rabies and Japanese encephalitis virus neutralizing antibodies concentrations were demonstrated by day 49, 7 days after a booster at 1 year, and in the majorly at 3 years postvaccination. The inclusion of rabies vaccine in the expanded program on immunization should be considered in rabies endemic countries.

摘要

对幼儿同时接种纯化鸡胚细胞狂犬病疫苗和日本脑炎疫苗后,在49天时、1岁加强免疫7天后以及主要在接种疫苗3年后,均显示出足够的狂犬病和日本脑炎病毒中和抗体浓度。狂犬病流行国家应考虑将狂犬病疫苗纳入扩大免疫规划。

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